TY - JOUR
T1 - New insights into nucleosome and chromatin structure
T2 - An ordered state or a disordered affair?
AU - Luger, Karolin
AU - Dechassa, Mekonnen L.
AU - Tremethick, David J.
PY - 2012/7
Y1 - 2012/7
N2 - The compaction of genomic DNA into chromatin has profound implications for the regulation of key processes such as transcription, replication and DNA repair. Nucleosomes, the repeating building blocks of chromatin, vary in the composition of their histone protein components. This is the result of the incorporation of variant histones and post-translational modifications of histone amino acid side chains. The resulting changes in nucleosome structure, stability and dynamics affect the compaction of nucleosomal arrays into higher-order structures. It is becoming clear that chromatin structures are not nearly as uniform and regular as previously assumed. This implies that chromatin structure must also be viewed in the context of specific biological functions.
AB - The compaction of genomic DNA into chromatin has profound implications for the regulation of key processes such as transcription, replication and DNA repair. Nucleosomes, the repeating building blocks of chromatin, vary in the composition of their histone protein components. This is the result of the incorporation of variant histones and post-translational modifications of histone amino acid side chains. The resulting changes in nucleosome structure, stability and dynamics affect the compaction of nucleosomal arrays into higher-order structures. It is becoming clear that chromatin structures are not nearly as uniform and regular as previously assumed. This implies that chromatin structure must also be viewed in the context of specific biological functions.
UR - http://www.scopus.com/inward/record.url?scp=84862732690&partnerID=8YFLogxK
U2 - 10.1038/nrm3382
DO - 10.1038/nrm3382
M3 - Review article
SN - 1471-0072
VL - 13
SP - 436
EP - 447
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 7
ER -