Nitric oxide contributes to the resistance of young SJL/J mice to experimental autoimmune encephalomyelitis

Maria A. Staykova; Susan A. Fordham; Gavin J. Bartell; William B. Cowden; David O. Willenborg

doi:10.1016/j.jneuroim.2006.03.015

Nitric oxide contributes to the resistance of young SJL/J mice to experimental autoimmune encephalomyelitis

Maria A. Staykova^*, Susan A. Fordham, Gavin J. Bartell, William B. Cowden, David O. Willenborg

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

EAE development in SJL/J mice is age and sex dependent: young males are EAE resistant; females and adult males are EAE susceptible. By studying splenocytes' IFNγ and NO production and the induction or the suppression of actively induced EAE by manipulating NO systemic levels, we provide evidence that the failure of young male SJL/J mice to develop EAE lies in the activation of the innate immune system by the immunising stimulus.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	176
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2006.03.015
Publication status	Published - Jul 2006

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10.1016/j.jneuroim.2006.03.015

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title = "Nitric oxide contributes to the resistance of young SJL/J mice to experimental autoimmune encephalomyelitis",

abstract = "EAE development in SJL/J mice is age and sex dependent: young males are EAE resistant; females and adult males are EAE susceptible. By studying splenocytes' IFNγ and NO production and the induction or the suppression of actively induced EAE by manipulating NO systemic levels, we provide evidence that the failure of young male SJL/J mice to develop EAE lies in the activation of the innate immune system by the immunising stimulus.",

keywords = "EAE, NO, Sex",

author = "Staykova, {Maria A.} and Fordham, {Susan A.} and Bartell, {Gavin J.} and Cowden, {William B.} and Willenborg, {David O.}",

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AU - Staykova, Maria A.

AU - Fordham, Susan A.

AU - Bartell, Gavin J.

AU - Cowden, William B.

AU - Willenborg, David O.

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AB - EAE development in SJL/J mice is age and sex dependent: young males are EAE resistant; females and adult males are EAE susceptible. By studying splenocytes' IFNγ and NO production and the induction or the suppression of actively induced EAE by manipulating NO systemic levels, we provide evidence that the failure of young male SJL/J mice to develop EAE lies in the activation of the innate immune system by the immunising stimulus.

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ER -

Nitric oxide contributes to the resistance of young SJL/J mice to experimental autoimmune encephalomyelitis

Abstract

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