NLRP9b: A novel RNA-sensing inflammasome complex

Chinh Ngo; Si Ming Man

doi:10.1038/cr.2017.93

NLRP9b: A novel RNA-sensing inflammasome complex

Chinh Ngo, Si Ming Man^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

Abstract

Inflammasome sensors recognize pathogens and danger signals and assemble an immune signaling complex, which induces the secretion of pro-inflammatory cytokines IL-1β and IL-18, and pyroptosis. A new study published in Nature now describes a new inflammasome sensor NLRP9b in intestinal epithelial cells, which in concert with the RNA sensor DHX9, recognize short dsRNA from Rotavirus.

Original language	English
Pages (from-to)	1302-1303
Number of pages	2
Journal	Cell Research
Volume	27
Issue number	11
DOIs	https://doi.org/10.1038/cr.2017.93
Publication status	Published - 1 Nov 2017

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10.1038/cr.2017.93

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title = "NLRP9b: A novel RNA-sensing inflammasome complex",

abstract = "Inflammasome sensors recognize pathogens and danger signals and assemble an immune signaling complex, which induces the secretion of pro-inflammatory cytokines IL-1β and IL-18, and pyroptosis. A new study published in Nature now describes a new inflammasome sensor NLRP9b in intestinal epithelial cells, which in concert with the RNA sensor DHX9, recognize short dsRNA from Rotavirus.",

author = "Chinh Ngo and Man, {Si Ming}",

note = "Publisher Copyright: {\textcopyright} 2017 IBCB, SIBS, CAS.",

year = "2017",

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AU - Ngo, Chinh

AU - Man, Si Ming

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N2 - Inflammasome sensors recognize pathogens and danger signals and assemble an immune signaling complex, which induces the secretion of pro-inflammatory cytokines IL-1β and IL-18, and pyroptosis. A new study published in Nature now describes a new inflammasome sensor NLRP9b in intestinal epithelial cells, which in concert with the RNA sensor DHX9, recognize short dsRNA from Rotavirus.

AB - Inflammasome sensors recognize pathogens and danger signals and assemble an immune signaling complex, which induces the secretion of pro-inflammatory cytokines IL-1β and IL-18, and pyroptosis. A new study published in Nature now describes a new inflammasome sensor NLRP9b in intestinal epithelial cells, which in concert with the RNA sensor DHX9, recognize short dsRNA from Rotavirus.

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U2 - 10.1038/cr.2017.93

DO - 10.1038/cr.2017.93

M3 - Review article

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JO - Cell Research

JF - Cell Research

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ER -

NLRP9b: A novel RNA-sensing inflammasome complex

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