No associations between telomere length and age-sensitive indicators of physical function in mid and later life

Karen Anne Mather; Anthony Francis Jorm; Peter John Milburn; Xiaoyun Tan; Simon Easteal; Helen Christensen

doi:10.1093/gerona/glq050

No associations between telomere length and age-sensitive indicators of physical function in mid and later life

Karen Anne Mather, Anthony Francis Jorm, Peter John Milburn, Xiaoyun Tan, Simon Easteal, Helen Christensen

Research output: Contribution to journal › Article › peer-review

44 Citations (SciVal)

Abstract

Telomere length, which declines with age, has been hypothesized to act as an indicator of biological aging. If it fulfills this purpose, shorter telomere length should correlate with age-related loss of physical function, independent of age. In this cross-sectional Australian population study, the associations between peripheral blood leukocyte telomere length and age-sensitive indicators of physical function (lung function, blood pressure, and grip strength) were examined in two narrow age range cohorts aged 44-49 years (n = 351) and 64-70 years (n = 295). Telomere length was correlated with systolic blood pressure but only for women of the younger cohort and in the opposite direction to that expected (partial r =.181, p =.017). This evidence does not provide support for the hypothesis that telomere length is related to age-associated changes in physical function.

Original language	English
Pages (from-to)	792-799
Number of pages	8
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	65 A
Issue number	8
DOIs	https://doi.org/10.1093/gerona/glq050
Publication status	Published - Aug 2010

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title = "No associations between telomere length and age-sensitive indicators of physical function in mid and later life",

abstract = "Telomere length, which declines with age, has been hypothesized to act as an indicator of biological aging. If it fulfills this purpose, shorter telomere length should correlate with age-related loss of physical function, independent of age. In this cross-sectional Australian population study, the associations between peripheral blood leukocyte telomere length and age-sensitive indicators of physical function (lung function, blood pressure, and grip strength) were examined in two narrow age range cohorts aged 44-49 years (n = 351) and 64-70 years (n = 295). Telomere length was correlated with systolic blood pressure but only for women of the younger cohort and in the opposite direction to that expected (partial r =.181, p =.017). This evidence does not provide support for the hypothesis that telomere length is related to age-associated changes in physical function.",

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No associations between telomere length and age-sensitive indicators of physical function in mid and later life. / Mather, Karen Anne; Jorm, Anthony Francis; Milburn, Peter John et al.
In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 65 A, No. 8, 08.2010, p. 792-799.

Research output: Contribution to journal › Article › peer-review

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T1 - No associations between telomere length and age-sensitive indicators of physical function in mid and later life

AU - Mather, Karen Anne

AU - Jorm, Anthony Francis

AU - Milburn, Peter John

AU - Tan, Xiaoyun

AU - Easteal, Simon

AU - Christensen, Helen

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AB - Telomere length, which declines with age, has been hypothesized to act as an indicator of biological aging. If it fulfills this purpose, shorter telomere length should correlate with age-related loss of physical function, independent of age. In this cross-sectional Australian population study, the associations between peripheral blood leukocyte telomere length and age-sensitive indicators of physical function (lung function, blood pressure, and grip strength) were examined in two narrow age range cohorts aged 44-49 years (n = 351) and 64-70 years (n = 295). Telomere length was correlated with systolic blood pressure but only for women of the younger cohort and in the opposite direction to that expected (partial r =.181, p =.017). This evidence does not provide support for the hypothesis that telomere length is related to age-associated changes in physical function.

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KW - Biomarker

KW - Physical function

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JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

IS - 8

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No associations between telomere length and age-sensitive indicators of physical function in mid and later life

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