Notch signaling in the immune system

Gerard F. Hoyne

doi:10.1189/jlb.0303089

Notch signaling in the immune system

Gerard F. Hoyne^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Abstract

Notch signaling plays a preeminent role during development in not only regulating cell fate decisions, but it can also influence growth and survival of progenitor cells. In the immune system, Notch is required for the maintenance of hematopoietic stem cells and in directing T- versus B-lineage commitment. In this review, I will summarize some of the recent findings relating to the function of Notch in the immune system during lymphocyte development and in the generation and function of mature cells.

Original language	English
Pages (from-to)	971-981
Number of pages	11
Journal	Journal of Leukocyte Biology
Volume	74
Issue number	6
DOIs	https://doi.org/10.1189/jlb.0303089
Publication status	Published - Dec 2003

Access to Document

10.1189/jlb.0303089

Cite this

@article{b585ba3d13f9485c8aee89063e4bc0dd,

title = "Notch signaling in the immune system",

abstract = "Notch signaling plays a preeminent role during development in not only regulating cell fate decisions, but it can also influence growth and survival of progenitor cells. In the immune system, Notch is required for the maintenance of hematopoietic stem cells and in directing T- versus B-lineage commitment. In this review, I will summarize some of the recent findings relating to the function of Notch in the immune system during lymphocyte development and in the generation and function of mature cells.",

keywords = "Development, Haematopiesis, Lymphocytes, Lymphopoiesis",

author = "Hoyne, {Gerard F.}",

year = "2003",

month = dec,

doi = "10.1189/jlb.0303089",

language = "English",

volume = "74",

pages = "971--981",

journal = "Journal of Leukocyte Biology",

issn = "0741-5400",

publisher = "Oxford University Press",

number = "6",

}

TY - JOUR

T1 - Notch signaling in the immune system

AU - Hoyne, Gerard F.

PY - 2003/12

Y1 - 2003/12

N2 - Notch signaling plays a preeminent role during development in not only regulating cell fate decisions, but it can also influence growth and survival of progenitor cells. In the immune system, Notch is required for the maintenance of hematopoietic stem cells and in directing T- versus B-lineage commitment. In this review, I will summarize some of the recent findings relating to the function of Notch in the immune system during lymphocyte development and in the generation and function of mature cells.

AB - Notch signaling plays a preeminent role during development in not only regulating cell fate decisions, but it can also influence growth and survival of progenitor cells. In the immune system, Notch is required for the maintenance of hematopoietic stem cells and in directing T- versus B-lineage commitment. In this review, I will summarize some of the recent findings relating to the function of Notch in the immune system during lymphocyte development and in the generation and function of mature cells.

KW - Development

KW - Haematopiesis

KW - Lymphocytes

KW - Lymphopoiesis

UR - http://www.scopus.com/inward/record.url?scp=0348047540&partnerID=8YFLogxK

U2 - 10.1189/jlb.0303089

DO - 10.1189/jlb.0303089

M3 - Review article

SN - 0741-5400

VL - 74

SP - 971

EP - 981

JO - Journal of Leukocyte Biology

JF - Journal of Leukocyte Biology

IS - 6

ER -

Notch signaling in the immune system

Abstract

Access to Document

Other files and links

Fingerprint

Cite this