Novel scientific approaches and future research directions in understanding ITP

Sarah M. Hicks, Lucy A. Coupland, Anila Jahangiri, Philip Y. Choi, Elizabeth E. Gardiner*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    12 Citations (Scopus)


    Diagnosis of immune thrombocytopenia (ITP) and prediction of response to therapy remain significant and constant challenges in hematology. In patients who present with ITP, the platelet count is frequently used as a surrogate marker for disease severity, and so often determines the need for therapy. Although there is a clear link between thrombocytopenia and hemostasis, a direct correlation between the extent of thrombocytopenia and bleeding symptoms, especially at lower platelet counts is lacking. Thus, bleeding in ITP is heterogeneous, unpredictable, and nearly always based on a multitude of risk factors, beyond the platelet count. The development of an evidence-based, validated risk stratification model for ITP treatment is a major goal in the ITP community and this review discusses new laboratory approaches to evaluate the various pathobiologies of ITP that may inform such a model.

    Original languageEnglish
    Pages (from-to)315-321
    Number of pages7
    Issue number3
    Publication statusPublished - 2 Apr 2020


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