On the Endo/Exo Stereoselectivity of Intramolecular Diels-Alder Reactions of Hexadienylacrylates: An Interesting Failure of Density Functional Theory

(Matrix Presented) A combined experimental and computational study of endo/exo stereoselectivity in a series of IMDA reactions of hexadienylacrylates has found that DFT makes erroneous predictions when the endo and exo transition states possess differing degrees of conjugation. These problems are overcome by carrying out calculations at the MP2 level of theory, which gives remarkably accurate Boltzmann distributions of products. These findings are used to predict ways to obtain either endo- or exo-cycloadducts exclusively.