TY - JOUR
T1 - Oncogenesis and cancer stem cells
T2 - Current opinions and future directions
AU - Cheng, Xiaoyu
AU - O'Neill, Helen C.
PY - 2009/11
Y1 - 2009/11
N2 - There is increasing evidence to show that only a subset of cancer cells drives the growth and progression of a tumour. These cells share similar properties with normal stem cells and are termed 'cancer stem cells'. Cancer stem cells have been identified in acute myeloid leukaemia and in some solid tumours by their distinct expression of cell surface antigens. Their long-term, self-renewing capacity is thought to be a determining factor in the maintenance and regrowth of the tumour. Studies on haematopoietic cancers show that important signalling pathways and genes for normal haematopoiesis, such as Wnt, NF-κB, Notch, hedgehog (Hh) and Bmi1, are oncogenic, thereby potentially involved in cancer stem cell regulation. Elimination of cancer stem cells in tumours could result in the degeneration of downstream cells, which makes them potential targets for new cancer therapies.
AB - There is increasing evidence to show that only a subset of cancer cells drives the growth and progression of a tumour. These cells share similar properties with normal stem cells and are termed 'cancer stem cells'. Cancer stem cells have been identified in acute myeloid leukaemia and in some solid tumours by their distinct expression of cell surface antigens. Their long-term, self-renewing capacity is thought to be a determining factor in the maintenance and regrowth of the tumour. Studies on haematopoietic cancers show that important signalling pathways and genes for normal haematopoiesis, such as Wnt, NF-κB, Notch, hedgehog (Hh) and Bmi1, are oncogenic, thereby potentially involved in cancer stem cell regulation. Elimination of cancer stem cells in tumours could result in the degeneration of downstream cells, which makes them potential targets for new cancer therapies.
KW - Acute myeloid leukaemia
KW - Cancer stem cell
KW - Haematopoietic stem cell
KW - Niche
KW - Oncogenesis
KW - Signalling pathways
UR - http://www.scopus.com/inward/record.url?scp=77951155573&partnerID=8YFLogxK
U2 - 10.1111/j.1582-4934.2008.00664.x
DO - 10.1111/j.1582-4934.2008.00664.x
M3 - Article
SN - 1582-1838
VL - 13
SP - 4377
EP - 4384
JO - Journal of Cellular and Molecular Medicine
JF - Journal of Cellular and Molecular Medicine
IS - 11-12
ER -