One-pot five-component synthesis of highly functionalized piperidines using oxalic acid dihydrate as a homogenous catalyst

Seyed Sajad Sajadikhah, Malek Taher Maghsoodlou*, Nourallah Hazeri, Sayyed Mostafa Habibi-Khorassani, Anthony C. Willis

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    63 Citations (Scopus)

    Abstract

    An efficient green protocol is described for the preparation of highly functionalized piperidines via a one-pot five-component reaction between aromatic aldehydes, anilines and β-ketoesters in the presence of oxalic acid dihydrate as catalyst in ethanol at ambient temperature. The structure as well as the relative stereochemistry of these compounds was confirmed by single X-ray crystallographic analysis.

    Original languageEnglish
    Pages (from-to)569-572
    Number of pages4
    JournalChinese Chemical Letters
    Volume23
    Issue number5
    DOIs
    Publication statusPublished - May 2012

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