Optimization of aqueous SI-ATRP grafting of poly(oligo(ethylene glycol) methacrylate) brushes from benzyl chloride macroinitiator surfaces

Andrew E. Rodda; Francesca Ercole; David R. Nisbet; John S. Forsythe; Laurence Meagher

doi:10.1002/mabi.201400512

Optimization of aqueous SI-ATRP grafting of poly(oligo(ethylene glycol) methacrylate) brushes from benzyl chloride macroinitiator surfaces

Andrew E. Rodda^*, Francesca Ercole, David R. Nisbet, John S. Forsythe, Laurence Meagher

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Poly(oligo(ethylene glycol) methacrylate) (pOEGMA) brushes were grafted via surface-initiated atom transfer radical polymerization (SI-ATRP) from a poly(styrene-co-vinylbenzyl chloride) macroinitiator. While bromoisobutyryl initiator groups are most commonly used for this purpose, benzyl chloride initiators may be advantageous for some applications due to superior stability. Water-only graft solutions produced thicker brush coatings with superior low fouling properties (low protein adsorption and cell adhesion) versus mixed water/alcohol solutions. Coatings produced using 475 Da OEGMA (methyl ether terminated) further reduced non-specific interactions compared to 360 Da OEGMA (hydroxyl terminated). Initiator density had minimal effect on low fouling properties.

Original language	English
Pages (from-to)	799-811
Number of pages	13
Journal	Macromolecular Bioscience
Volume	15
Issue number	6
DOIs	https://doi.org/10.1002/mabi.201400512
Publication status	Published - 1 Jun 2015

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title = "Optimization of aqueous SI-ATRP grafting of poly(oligo(ethylene glycol) methacrylate) brushes from benzyl chloride macroinitiator surfaces",

abstract = "Poly(oligo(ethylene glycol) methacrylate) (pOEGMA) brushes were grafted via surface-initiated atom transfer radical polymerization (SI-ATRP) from a poly(styrene-co-vinylbenzyl chloride) macroinitiator. While bromoisobutyryl initiator groups are most commonly used for this purpose, benzyl chloride initiators may be advantageous for some applications due to superior stability. Water-only graft solutions produced thicker brush coatings with superior low fouling properties (low protein adsorption and cell adhesion) versus mixed water/alcohol solutions. Coatings produced using 475 Da OEGMA (methyl ether terminated) further reduced non-specific interactions compared to 360 Da OEGMA (hydroxyl terminated). Initiator density had minimal effect on low fouling properties.",

keywords = "aqueous ATRP, benzyl chloride, macroinitiator, protein fouling, surface initiated ATRP",

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note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

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AU - Rodda, Andrew E.

AU - Ercole, Francesca

AU - Nisbet, David R.

AU - Forsythe, John S.

AU - Meagher, Laurence

PY - 2015/6/1

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N2 - Poly(oligo(ethylene glycol) methacrylate) (pOEGMA) brushes were grafted via surface-initiated atom transfer radical polymerization (SI-ATRP) from a poly(styrene-co-vinylbenzyl chloride) macroinitiator. While bromoisobutyryl initiator groups are most commonly used for this purpose, benzyl chloride initiators may be advantageous for some applications due to superior stability. Water-only graft solutions produced thicker brush coatings with superior low fouling properties (low protein adsorption and cell adhesion) versus mixed water/alcohol solutions. Coatings produced using 475 Da OEGMA (methyl ether terminated) further reduced non-specific interactions compared to 360 Da OEGMA (hydroxyl terminated). Initiator density had minimal effect on low fouling properties.

AB - Poly(oligo(ethylene glycol) methacrylate) (pOEGMA) brushes were grafted via surface-initiated atom transfer radical polymerization (SI-ATRP) from a poly(styrene-co-vinylbenzyl chloride) macroinitiator. While bromoisobutyryl initiator groups are most commonly used for this purpose, benzyl chloride initiators may be advantageous for some applications due to superior stability. Water-only graft solutions produced thicker brush coatings with superior low fouling properties (low protein adsorption and cell adhesion) versus mixed water/alcohol solutions. Coatings produced using 475 Da OEGMA (methyl ether terminated) further reduced non-specific interactions compared to 360 Da OEGMA (hydroxyl terminated). Initiator density had minimal effect on low fouling properties.

KW - aqueous ATRP

KW - benzyl chloride

KW - macroinitiator

KW - protein fouling

KW - surface initiated ATRP

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DO - 10.1002/mabi.201400512

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JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

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ER -

Optimization of aqueous SI-ATRP grafting of poly(oligo(ethylene glycol) methacrylate) brushes from benzyl chloride macroinitiator surfaces

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