Organic osmolyte channels: A comparative view

Pauline R. Junankar, Kiaran Kirk*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    49 Citations (Scopus)

    Abstract

    Cells respond to osmotic swelling by releasing inorganic ions and small organic molecules (organic osmolytes). In many cell-types, osmotic swelling results in the activation of an outwardly-rectifying anion-selective current. The channel underlying this current has a significant permeability to a number of organic osmolytes and may play a role in the hypoosmotically-activated efflux of these compounds. However, there is also evidence that the volume-regulatory efflux of organic osmolytes involves other pathways which may be selective for neutral osmolytes over anions.

    Original languageEnglish
    Pages (from-to)355-360
    Number of pages6
    JournalCellular Physiology and Biochemistry
    Volume10
    Issue number5-6
    DOIs
    Publication statusPublished - 2000

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