Abstract
Cells respond to osmotic swelling by releasing inorganic ions and small organic molecules (organic osmolytes). In many cell-types, osmotic swelling results in the activation of an outwardly-rectifying anion-selective current. The channel underlying this current has a significant permeability to a number of organic osmolytes and may play a role in the hypoosmotically-activated efflux of these compounds. However, there is also evidence that the volume-regulatory efflux of organic osmolytes involves other pathways which may be selective for neutral osmolytes over anions.
Original language | English |
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Pages (from-to) | 355-360 |
Number of pages | 6 |
Journal | Cellular Physiology and Biochemistry |
Volume | 10 |
Issue number | 5-6 |
DOIs | |
Publication status | Published - 2000 |