Os2–Os4Switch Controls DNA Knotting and Anticancer Activity

Ying Fu; María J. Romero; Luca Salassa; Xi Cheng; Abraha Habtemariam; Guy J. Clarkson; Ivan Prokes; Alison Rodger; Giovanni Costantini; Peter J. Sadler

doi:10.1002/anie.201602995

Os₂–Os₄Switch Controls DNA Knotting and Anticancer Activity

Ying Fu, María J. Romero, Luca Salassa, Xi Cheng, Abraha Habtemariam, Guy J. Clarkson, Ivan Prokes, Alison Rodger, Giovanni Costantini, Peter J. Sadler^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Dinuclear trihydroxido-bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido-bridged Os^II–arene fragments by a bridging di-imine to form a metallacycle framework results in strong antiproliferative activity towards cancer cells and distinctive knotting of DNA. The shortened spacer length reduces biological activity and stability in solution towards decomposition to biologically inactive dimers. Significant differences in behavior toward plasmid DNA condensation are correlated with biological activity.

Original language	English
Pages (from-to)	8909-8912
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	55
Issue number	31
DOIs	https://doi.org/10.1002/anie.201602995
Publication status	Published - 25 Jul 2016
Externally published	Yes

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10.1002/anie.201602995

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title = "Os2–Os4Switch Controls DNA Knotting and Anticancer Activity",

abstract = "Dinuclear trihydroxido-bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido-bridged OsII–arene fragments by a bridging di-imine to form a metallacycle framework results in strong antiproliferative activity towards cancer cells and distinctive knotting of DNA. The shortened spacer length reduces biological activity and stability in solution towards decomposition to biologically inactive dimers. Significant differences in behavior toward plasmid DNA condensation are correlated with biological activity.",

keywords = "cancer, DNA, organometallic, osmium, supramolecular",

author = "Ying Fu and Romero, {Mar{\'i}a J.} and Luca Salassa and Xi Cheng and Abraha Habtemariam and Clarkson, {Guy J.} and Ivan Prokes and Alison Rodger and Giovanni Costantini and Sadler, {Peter J.}",

note = "Publisher Copyright: {\textcopyright} 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.",

year = "2016",

month = jul,

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doi = "10.1002/anie.201602995",

language = "English",

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TY - JOUR

T1 - Os2–Os4Switch Controls DNA Knotting and Anticancer Activity

AU - Fu, Ying

AU - Romero, María J.

AU - Salassa, Luca

AU - Cheng, Xi

AU - Habtemariam, Abraha

AU - Clarkson, Guy J.

AU - Prokes, Ivan

AU - Rodger, Alison

AU - Costantini, Giovanni

AU - Sadler, Peter J.

PY - 2016/7/25

Y1 - 2016/7/25

N2 - Dinuclear trihydroxido-bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido-bridged OsII–arene fragments by a bridging di-imine to form a metallacycle framework results in strong antiproliferative activity towards cancer cells and distinctive knotting of DNA. The shortened spacer length reduces biological activity and stability in solution towards decomposition to biologically inactive dimers. Significant differences in behavior toward plasmid DNA condensation are correlated with biological activity.

AB - Dinuclear trihydroxido-bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido-bridged OsII–arene fragments by a bridging di-imine to form a metallacycle framework results in strong antiproliferative activity towards cancer cells and distinctive knotting of DNA. The shortened spacer length reduces biological activity and stability in solution towards decomposition to biologically inactive dimers. Significant differences in behavior toward plasmid DNA condensation are correlated with biological activity.

KW - cancer

KW - DNA

KW - organometallic

KW - osmium

KW - supramolecular

UR - http://www.scopus.com/inward/record.url?scp=84971614169&partnerID=8YFLogxK

U2 - 10.1002/anie.201602995

DO - 10.1002/anie.201602995

M3 - Article

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AN - SCOPUS:84971614169

SN - 1433-7851

VL - 55

SP - 8909

EP - 8912

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 31

ER -

Os₂–Os₄Switch Controls DNA Knotting and Anticancer Activity

Abstract

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