Oxidation of threonine residues with IBX reagents

P. Manohari Abeysinghe; Yu Han; Margaret M. Harding

doi:10.1016/j.tetlet.2009.03.107

Oxidation of threonine residues with IBX reagents

P. Manohari Abeysinghe, Yu Han, Margaret M. Harding^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The treatment of protected Thr peptides with excess polymer-bound IBX effects sequential oxidation of the Thr secondary alcohol to the ketone, followed by hydroxylation of the alpha carbon of the Thr residues with loss of stereochemistry at this position.

Original language	English
Pages (from-to)	2601-2604
Number of pages	4
Journal	Tetrahedron Letters
Volume	50
Issue number	21
DOIs	https://doi.org/10.1016/j.tetlet.2009.03.107
Publication status	Published - 27 May 2009
Externally published	Yes

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10.1016/j.tetlet.2009.03.107

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@article{4dc45167f78e45b39389f0985c70ae55,

title = "Oxidation of threonine residues with IBX reagents",

abstract = "The treatment of protected Thr peptides with excess polymer-bound IBX effects sequential oxidation of the Thr secondary alcohol to the ketone, followed by hydroxylation of the alpha carbon of the Thr residues with loss of stereochemistry at this position.",

keywords = "Antifreeze proteins, Threonine oxidation, o-Iodoxybenzoic acid (IBX)",

author = "Abeysinghe, {P. Manohari} and Yu Han and Harding, {Margaret M.}",

year = "2009",

month = may,

day = "27",

doi = "10.1016/j.tetlet.2009.03.107",

language = "English",

volume = "50",

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journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd.",

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T1 - Oxidation of threonine residues with IBX reagents

AU - Abeysinghe, P. Manohari

AU - Han, Yu

AU - Harding, Margaret M.

PY - 2009/5/27

Y1 - 2009/5/27

N2 - The treatment of protected Thr peptides with excess polymer-bound IBX effects sequential oxidation of the Thr secondary alcohol to the ketone, followed by hydroxylation of the alpha carbon of the Thr residues with loss of stereochemistry at this position.

AB - The treatment of protected Thr peptides with excess polymer-bound IBX effects sequential oxidation of the Thr secondary alcohol to the ketone, followed by hydroxylation of the alpha carbon of the Thr residues with loss of stereochemistry at this position.

KW - Antifreeze proteins

KW - Threonine oxidation

KW - o-Iodoxybenzoic acid (IBX)

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U2 - 10.1016/j.tetlet.2009.03.107

DO - 10.1016/j.tetlet.2009.03.107

M3 - Article

SN - 0040-4039

VL - 50

SP - 2601

EP - 2604

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 21

ER -

Oxidation of threonine residues with IBX reagents

Abstract

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