Parallel palaeogenomic transects reveal complex genetic history of early European farmers

Mark Lipson; Anna Szécsényi-Nagy; Swapan Mallick; Annamária Pósa; Balázs Stégmár; Victoria Keerl; Nadin Rohland; Kristin Stewardson; Matthew Ferry; Megan Michel; Jonas Oppenheimer; Nasreen Broomandkhoshbacht; Eadaoin Harney; Susanne Nordenfelt; Bastien Llamas; Balázs Mende Gusztáv; Kitti Köhler; Krisztián Oross; Mária Bondár; Tibor Marton; Anett Osztás; János Jakucs; Tibor Paluch; Ferenc Horváth; Piroska Csengeri; Judit Koós; Katalin Sebok; Alexandra Anders; Pál Raczky; Judit Regenye; Judit P. Barna; Szilvia Fábián; Gábor Serlegi; Zoltán Toldi; Emese Gyöngyvér Nagy; János Dani; Erika Molnár; György Pálfi; László Márk; Béla Melegh; Zsolt Bánfai; László Domboróczki; Javier Fernández-Eraso; José Antonio Mujika-Alustiza; Carmen Alonso Fernández; Javier Jiménez Echevarría; Ruth Bollongino; Jörg Orschiedt; Kerstin Schierhold; Alan Cooper

doi:10.1038/nature24476

Parallel palaeogenomic transects reveal complex genetic history of early European farmers

Mark Lipson^*, Anna Szécsényi-Nagy, Swapan Mallick, Annamária Pósa, Balázs Stégmár, Victoria Keerl, Nadin Rohland, Kristin Stewardson, Matthew Ferry, Megan Michel, Jonas Oppenheimer, Nasreen Broomandkhoshbacht, Eadaoin Harney, Susanne Nordenfelt, Bastien Llamas, Balázs Mende Gusztáv, Kitti Köhler, Krisztián Oross, Mária Bondár, Tibor MartonAnett Osztás, János Jakucs, Tibor Paluch, Ferenc Horváth, Piroska Csengeri, Judit Koós, Katalin Sebok, Alexandra Anders, Pál Raczky, Judit Regenye, Judit P. Barna, Szilvia Fábián, Gábor Serlegi, Zoltán Toldi, Emese Gyöngyvér Nagy, János Dani, Erika Molnár, György Pálfi, László Márk, Béla Melegh, Zsolt Bánfai, László Domboróczki, Javier Fernández-Eraso, José Antonio Mujika-Alustiza, Carmen Alonso Fernández, Javier Jiménez Echevarría, Ruth Bollongino, Jörg Orschiedt, Kerstin Schierhold, Alan Cooper

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

245 Citations (Scopus)

Abstract

Ancient DNA studies have established that Neolithic European populations were descended from Anatolian migrants who received a limited amount of admixture from resident hunter-gatherers. Many open questions remain, however, about the spatial and temporal dynamics of population interactions and admixture during the Neolithic period. Here we investigate the population dynamics of Neolithization across Europe using a high-resolution genome-wide ancient DNA dataset with a total of 180 samples, of which 130 are newly reported here, from the Neolithic and Chalcolithic periods of Hungary (6000-2900 bc, n = 100), Germany (5500-3000 bc, n = 42) and Spain (5500-2200 bc, n = 38). We find that genetic diversity was shaped predominantly by local processes, with varied sources and proportions of hunter-gatherer ancestry among the three regions and through time. Admixture between groups with different ancestry profiles was pervasive and resulted in observable population transformation across almost all cultural transitions. Our results shed new light on the ways in which gene flow reshaped European populations throughout the Neolithic period and demonstrate the potential of time-series-based sampling and modelling approaches to elucidate multiple dimensions of historical population interactions.

Original language	English
Pages (from-to)	368-372
Number of pages	5
Journal	Nature
Volume	551
Issue number	7680
DOIs	https://doi.org/10.1038/nature24476
Publication status	Published - 16 Nov 2017
Externally published	Yes

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Lipson, M., Szécsényi-Nagy, A., Mallick, S., Pósa, A., Stégmár, B., Keerl, V., Rohland, N., Stewardson, K., Ferry, M., Michel, M., Oppenheimer, J., Broomandkhoshbacht, N., Harney, E., Nordenfelt, S., Llamas, B., Gusztáv, B. M., Köhler, K., Oross, K., Bondár, M., ... Cooper, A. (2017). Parallel palaeogenomic transects reveal complex genetic history of early European farmers. Nature, 551(7680), 368-372. https://doi.org/10.1038/nature24476

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title = "Parallel palaeogenomic transects reveal complex genetic history of early European farmers",

abstract = "Ancient DNA studies have established that Neolithic European populations were descended from Anatolian migrants who received a limited amount of admixture from resident hunter-gatherers. Many open questions remain, however, about the spatial and temporal dynamics of population interactions and admixture during the Neolithic period. Here we investigate the population dynamics of Neolithization across Europe using a high-resolution genome-wide ancient DNA dataset with a total of 180 samples, of which 130 are newly reported here, from the Neolithic and Chalcolithic periods of Hungary (6000-2900 bc, n = 100), Germany (5500-3000 bc, n = 42) and Spain (5500-2200 bc, n = 38). We find that genetic diversity was shaped predominantly by local processes, with varied sources and proportions of hunter-gatherer ancestry among the three regions and through time. Admixture between groups with different ancestry profiles was pervasive and resulted in observable population transformation across almost all cultural transitions. Our results shed new light on the ways in which gene flow reshaped European populations throughout the Neolithic period and demonstrate the potential of time-series-based sampling and modelling approaches to elucidate multiple dimensions of historical population interactions.",

author = "Mark Lipson and Anna Sz{\'e}cs{\'e}nyi-Nagy and Swapan Mallick and Annam{\'a}ria P{\'o}sa and Bal{\'a}zs St{\'e}gm{\'a}r and Victoria Keerl and Nadin Rohland and Kristin Stewardson and Matthew Ferry and Megan Michel and Jonas Oppenheimer and Nasreen Broomandkhoshbacht and Eadaoin Harney and Susanne Nordenfelt and Bastien Llamas and Guszt{\'a}v, {Bal{\'a}zs Mende} and Kitti K{\"o}hler and Kriszti{\'a}n Oross and M{\'a}ria Bond{\'a}r and Tibor Marton and Anett Oszt{\'a}s and J{\'a}nos Jakucs and Tibor Paluch and Ferenc Horv{\'a}th and Piroska Csengeri and Judit Ko{\'o}s and Katalin Sebok and Alexandra Anders and P{\'a}l Raczky and Judit Regenye and Barna, {Judit P.} and Szilvia F{\'a}bi{\'a}n and G{\'a}bor Serlegi and Zolt{\'a}n Toldi and Nagy, {Emese Gy{\"o}ngyv{\'e}r} and J{\'a}nos Dani and Erika Moln{\'a}r and Gy{\"o}rgy P{\'a}lfi and L{\'a}szl{\'o} M{\'a}rk and B{\'e}la Melegh and Zsolt B{\'a}nfai and L{\'a}szl{\'o} Dombor{\'o}czki and Javier Fern{\'a}ndez-Eraso and Mujika-Alustiza, {Jos{\'e} Antonio} and Fern{\'a}ndez, {Carmen Alonso} and Echevarr{\'i}a, {Javier Jim{\'e}nez} and Ruth Bollongino and J{\"o}rg Orschiedt and Kerstin Schierhold and Alan Cooper",

year = "2017",

month = nov,

day = "16",

doi = "10.1038/nature24476",

language = "English",

volume = "551",

pages = "368--372",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "7680",

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Lipson, M, Szécsényi-Nagy, A, Mallick, S, Pósa, A, Stégmár, B, Keerl, V, Rohland, N, Stewardson, K, Ferry, M, Michel, M, Oppenheimer, J, Broomandkhoshbacht, N, Harney, E, Nordenfelt, S, Llamas, B, Gusztáv, BM, Köhler, K, Oross, K, Bondár, M, Marton, T, Osztás, A, Jakucs, J, Paluch, T, Horváth, F, Csengeri, P, Koós, J, Sebok, K, Anders, A, Raczky, P, Regenye, J, Barna, JP, Fábián, S, Serlegi, G, Toldi, Z, Nagy, EG, Dani, J, Molnár, E, Pálfi, G, Márk, L, Melegh, B, Bánfai, Z, Domboróczki, L, Fernández-Eraso, J, Mujika-Alustiza, JA, Fernández, CA, Echevarría, JJ, Bollongino, R, Orschiedt, J, Schierhold, K & Cooper, A 2017, 'Parallel palaeogenomic transects reveal complex genetic history of early European farmers', Nature, vol. 551, no. 7680, pp. 368-372. https://doi.org/10.1038/nature24476

TY - JOUR

T1 - Parallel palaeogenomic transects reveal complex genetic history of early European farmers

AU - Lipson, Mark

AU - Szécsényi-Nagy, Anna

AU - Mallick, Swapan

AU - Pósa, Annamária

AU - Stégmár, Balázs

AU - Keerl, Victoria

AU - Rohland, Nadin

AU - Stewardson, Kristin

AU - Ferry, Matthew

AU - Michel, Megan

AU - Oppenheimer, Jonas

AU - Broomandkhoshbacht, Nasreen

AU - Harney, Eadaoin

AU - Nordenfelt, Susanne

AU - Llamas, Bastien

AU - Gusztáv, Balázs Mende

AU - Köhler, Kitti

AU - Oross, Krisztián

AU - Bondár, Mária

AU - Marton, Tibor

AU - Osztás, Anett

AU - Jakucs, János

AU - Paluch, Tibor

AU - Horváth, Ferenc

AU - Csengeri, Piroska

AU - Koós, Judit

AU - Sebok, Katalin

AU - Anders, Alexandra

AU - Raczky, Pál

AU - Regenye, Judit

AU - Barna, Judit P.

AU - Fábián, Szilvia

AU - Serlegi, Gábor

AU - Toldi, Zoltán

AU - Nagy, Emese Gyöngyvér

AU - Dani, János

AU - Molnár, Erika

AU - Pálfi, György

AU - Márk, László

AU - Melegh, Béla

AU - Bánfai, Zsolt

AU - Domboróczki, László

AU - Fernández-Eraso, Javier

AU - Mujika-Alustiza, José Antonio

AU - Fernández, Carmen Alonso

AU - Echevarría, Javier Jiménez

AU - Bollongino, Ruth

AU - Orschiedt, Jörg

AU - Schierhold, Kerstin

AU - Cooper, Alan

PY - 2017/11/16

Y1 - 2017/11/16

N2 - Ancient DNA studies have established that Neolithic European populations were descended from Anatolian migrants who received a limited amount of admixture from resident hunter-gatherers. Many open questions remain, however, about the spatial and temporal dynamics of population interactions and admixture during the Neolithic period. Here we investigate the population dynamics of Neolithization across Europe using a high-resolution genome-wide ancient DNA dataset with a total of 180 samples, of which 130 are newly reported here, from the Neolithic and Chalcolithic periods of Hungary (6000-2900 bc, n = 100), Germany (5500-3000 bc, n = 42) and Spain (5500-2200 bc, n = 38). We find that genetic diversity was shaped predominantly by local processes, with varied sources and proportions of hunter-gatherer ancestry among the three regions and through time. Admixture between groups with different ancestry profiles was pervasive and resulted in observable population transformation across almost all cultural transitions. Our results shed new light on the ways in which gene flow reshaped European populations throughout the Neolithic period and demonstrate the potential of time-series-based sampling and modelling approaches to elucidate multiple dimensions of historical population interactions.

AB - Ancient DNA studies have established that Neolithic European populations were descended from Anatolian migrants who received a limited amount of admixture from resident hunter-gatherers. Many open questions remain, however, about the spatial and temporal dynamics of population interactions and admixture during the Neolithic period. Here we investigate the population dynamics of Neolithization across Europe using a high-resolution genome-wide ancient DNA dataset with a total of 180 samples, of which 130 are newly reported here, from the Neolithic and Chalcolithic periods of Hungary (6000-2900 bc, n = 100), Germany (5500-3000 bc, n = 42) and Spain (5500-2200 bc, n = 38). We find that genetic diversity was shaped predominantly by local processes, with varied sources and proportions of hunter-gatherer ancestry among the three regions and through time. Admixture between groups with different ancestry profiles was pervasive and resulted in observable population transformation across almost all cultural transitions. Our results shed new light on the ways in which gene flow reshaped European populations throughout the Neolithic period and demonstrate the potential of time-series-based sampling and modelling approaches to elucidate multiple dimensions of historical population interactions.

UR - http://www.scopus.com/inward/record.url?scp=85034428872&partnerID=8YFLogxK

U2 - 10.1038/nature24476

DO - 10.1038/nature24476

M3 - Article

C2 - 29144465

AN - SCOPUS:85034428872

SN - 0028-0836

VL - 551

SP - 368

EP - 372

JO - Nature

JF - Nature

IS - 7680

ER -

Parallel palaeogenomic transects reveal complex genetic history of early European farmers

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