Paraoxonase polymorphisms, pesticide exposure and Parkinson's disease in a caucasian population

M. C. Taylor; D. G. Le Couteur; G. D. Mellick; P. G. Board

doi:10.1007/s007020070046

Paraoxonase polymorphisms, pesticide exposure and Parkinson's disease in a caucasian population

M. C. Taylor, D. G. Le Couteur, G. D. Mellick, P. G. Board^*

^*Corresponding author for this work

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40 Citations (Scopus)

Abstract

Parkinson's disease (PD) has been associated with exposure to pesticides and oxidative injury. The involvement of paraoxonase in both pesticide metabolism and lipid peroxidation suggests that it may play a role in the pathogenesis of PD. We examined the frequency of polymorphic alleles of the PON1 and PON2 genes in a sample of caucasian subjects with PD. The frequency distribution of these genotypes did not differ significantly between patients and controls, including those who had reported exposure to pesticides.

Original language	English
Pages (from-to)	979-983
Number of pages	5
Journal	Journal of Neural Transmission
Volume	107
Issue number	8-9
DOIs	https://doi.org/10.1007/s007020070046
Publication status	Published - 2000

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AB - Parkinson's disease (PD) has been associated with exposure to pesticides and oxidative injury. The involvement of paraoxonase in both pesticide metabolism and lipid peroxidation suggests that it may play a role in the pathogenesis of PD. We examined the frequency of polymorphic alleles of the PON1 and PON2 genes in a sample of caucasian subjects with PD. The frequency distribution of these genotypes did not differ significantly between patients and controls, including those who had reported exposure to pesticides.

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KW - Polymorphism

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Paraoxonase polymorphisms, pesticide exposure and Parkinson's disease in a caucasian population

Abstract

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