Pas-de-deux: African Plasmodium falciparum adaptations to sickle hemoglobin

Kai Matuschewski; Alexander G. Maier

doi:10.1016/j.pt.2022.01.009

Pas-de-deux: African Plasmodium falciparum adaptations to sickle hemoglobin

Kai Matuschewski^*, Alexander G. Maier

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

Abstract

The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying parasite genome signatures, termed P. falciparum sickle-associated (Pfsa) variants.

Original language	English
Pages (from-to)	267-268
Number of pages	2
Journal	Trends in Parasitology
Volume	38
Issue number	4
DOIs	https://doi.org/10.1016/j.pt.2022.01.009
Publication status	Published - Apr 2022

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10.1016/j.pt.2022.01.009

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title = "Pas-de-deux: African Plasmodium falciparum adaptations to sickle hemoglobin",

abstract = "The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying parasite genome signatures, termed P. falciparum sickle-associated (Pfsa) variants.",

keywords = "allele frequency, balanced polymorphism, genetic epidemiology, hemoglobin S, severe malaria, sickle cell",

author = "Kai Matuschewski and Maier, {Alexander G.}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

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doi = "10.1016/j.pt.2022.01.009",

language = "English",

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T2 - African Plasmodium falciparum adaptations to sickle hemoglobin

AU - Matuschewski, Kai

AU - Maier, Alexander G.

PY - 2022/4

Y1 - 2022/4

N2 - The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying parasite genome signatures, termed P. falciparum sickle-associated (Pfsa) variants.

AB - The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying parasite genome signatures, termed P. falciparum sickle-associated (Pfsa) variants.

KW - allele frequency

KW - balanced polymorphism

KW - genetic epidemiology

KW - hemoglobin S

KW - severe malaria

KW - sickle cell

UR - http://www.scopus.com/inward/record.url?scp=85124284498&partnerID=8YFLogxK

U2 - 10.1016/j.pt.2022.01.009

DO - 10.1016/j.pt.2022.01.009

M3 - Short survey

SN - 1471-4922

VL - 38

SP - 267

EP - 268

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 4

ER -

Pas-de-deux: African Plasmodium falciparum adaptations to sickle hemoglobin

Abstract

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