Pathophysiology of T follicular helper cells in humans and mice

Hideki Ueno*, Jacques Banchereau, Carola G. Vinuesa

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    357 Citations (Scopus)

    Abstract

    Follicular helper T cells (TFH cells) compose a heterogeneous subset of CD4 + T cells that induce the differentiation of B cells into plasma cells and memory cells. They are found within and in proximity to germinal centers in secondary lymphoid organs, and their memory compartment also circulates in the blood. Our knowledge on the biology of TFH cells has increased significantly during the past decade, largely as a result of mouse studies. However, recent studies on human TFH cells isolated from lymphoid organ and blood samples and recent observations on the developmental mechanism of human TFH cells have revealed both similarities and differences between human and mouse TFH cells. Here we present the similarities and differences between mouse and human lymphoid organ-resident TFH cells and discuss the role of TFH cells in response to vaccines and in disease pathogenesis.

    Original languageEnglish
    Pages (from-to)142-152
    Number of pages11
    JournalNature Immunology
    Volume16
    Issue number2
    DOIs
    Publication statusPublished - 16 Jan 2015

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