TY - JOUR
T1 - PD-L1 expression in papillary thyroid cancer with and without lymphocytic thyroiditis
T2 - a cross sectional study
AU - Fadia, Mitali
AU - Fookeerah, Prishila
AU - Ali, Sayed
AU - Shadbolt, Bruce
AU - Greenaway, Tim
AU - Perampalam, Sumathy
N1 - Publisher Copyright:
© 2020
PY - 2020/4
Y1 - 2020/4
N2 - The impact of concurrent autoimmune thyroid disease on the tumour microenvironment and disease progression in papillary thyroid cancer (PTC) is not well understood. Studies evaluating the programmed cell death ligand 1 (PD-L1) tumour expression in PTC have shown variable results, and the effect of lymphocytic thyroiditis (LT) on tumour PD-L1 expression has not been adequately assessed. The main aim of this study was to determine expression of PD-L1 in PTC with and without LT. We examined 81 PTC cases; 28.5% of all reviewed PTC had presence of LT. In PTC specimens without LT, tumour PD-L1 expression was significantly lower compared to PD-L1 expression in PTC with LT, 6.9% vs 39.1%, respectively. Expression of PD-L1 did not differ with PTC stage, even when sub-categorised according to the presence and absence of LT. Utility of PD- L1 expression as a prognostic marker in thyroid cancer needs to be interpreted with caution.
AB - The impact of concurrent autoimmune thyroid disease on the tumour microenvironment and disease progression in papillary thyroid cancer (PTC) is not well understood. Studies evaluating the programmed cell death ligand 1 (PD-L1) tumour expression in PTC have shown variable results, and the effect of lymphocytic thyroiditis (LT) on tumour PD-L1 expression has not been adequately assessed. The main aim of this study was to determine expression of PD-L1 in PTC with and without LT. We examined 81 PTC cases; 28.5% of all reviewed PTC had presence of LT. In PTC specimens without LT, tumour PD-L1 expression was significantly lower compared to PD-L1 expression in PTC with LT, 6.9% vs 39.1%, respectively. Expression of PD-L1 did not differ with PTC stage, even when sub-categorised according to the presence and absence of LT. Utility of PD- L1 expression as a prognostic marker in thyroid cancer needs to be interpreted with caution.
KW - PD-L1
KW - Papillary thyroid cancer
KW - lymphocytic thyroiditis
KW - programmed cell death ligand 1
KW - tumour microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85079872699&partnerID=8YFLogxK
U2 - 10.1016/j.pathol.2019.11.007
DO - 10.1016/j.pathol.2019.11.007
M3 - Article
SN - 0031-3025
VL - 52
SP - 318
EP - 322
JO - Pathology
JF - Pathology
IS - 3
ER -