Pd/tetraphosphine catalytic system for Cu-free Sonogashira reaction "on water"

Rong Zhou, Wei Wang, Zhi Jie Jiang, Hai Yan Fu, Xue Li Zheng, Chun Chun Zhang, Hua Chen, Rui Xiang Li*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

An efficient copper-free Sonogashira coupling reaction was performed on water at 100 °C with N,N,N′,N′-tetra(diphenylphosphinomethyl) pyridine-2,6-diamine (1) as a ligand, [Pd(η3-C3H 5)Cl]2 as a catalyst precursor and K3PO 4 as a base. Both aryl and heteroaryl halides were successfully alkynylated in this system, and a high turnover number (TON) up to 860000 was obtained with a catalyst loading as low as 1 ppm.

Original languageEnglish
Pages (from-to)746-751
Number of pages6
JournalCatalysis Science and Technology
Volume4
Issue number3
DOIs
Publication statusPublished - 1 Mar 2014
Externally publishedYes

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