PEO-PPO-PEO surfactant exfoliated graphene cyclodextrin drug carriers for photoresponsive release

Matthew D.J. Quinn; Tao Wang; Mohammad Al Kobaisi; Vincent S.J. Craig; Shannon M. Notley

doi:10.1016/j.matchemphys.2017.11.012

PEO-PPO-PEO surfactant exfoliated graphene cyclodextrin drug carriers for photoresponsive release

Matthew D.J. Quinn^*, Tao Wang, Mohammad Al Kobaisi, Vincent S.J. Craig, Shannon M. Notley

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Liquid exfoliated graphene sheets were incorporated within α-cyclodextrin-triblock copolymer supramolecular hydrogels prepared with a range of polyethylene oxide and polypropylene oxide block sizes and ratios allowing control over the release properties. The strong photothermal activity of graphene was employed to externally activate drug release from within the gels using near-infrared (NIR) irradiation. These supramolecular hybrid hydrogels showed thermoreversible changes in viscosity, which is necessary for an injectable, multiple release point drug delivery depot. This hybrid graphene-surfactant-α-CD gel system with thermoreversible properties is demonstrated herein to be externally NIR activated to induce controllable drug release.

Original language	English
Pages (from-to)	154-163
Number of pages	10
Journal	Materials Chemistry and Physics
Volume	205
DOIs	https://doi.org/10.1016/j.matchemphys.2017.11.012
Publication status	Published - 1 Feb 2018

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10.1016/j.matchemphys.2017.11.012

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title = "PEO-PPO-PEO surfactant exfoliated graphene cyclodextrin drug carriers for photoresponsive release",

abstract = "Liquid exfoliated graphene sheets were incorporated within α-cyclodextrin-triblock copolymer supramolecular hydrogels prepared with a range of polyethylene oxide and polypropylene oxide block sizes and ratios allowing control over the release properties. The strong photothermal activity of graphene was employed to externally activate drug release from within the gels using near-infrared (NIR) irradiation. These supramolecular hybrid hydrogels showed thermoreversible changes in viscosity, which is necessary for an injectable, multiple release point drug delivery depot. This hybrid graphene-surfactant-α-CD gel system with thermoreversible properties is demonstrated herein to be externally NIR activated to induce controllable drug release.",

keywords = "2D, Drug release, Graphene, Hydrogel, Near-infrared, Photothermal",

author = "Quinn, {Matthew D.J.} and Tao Wang and {Al Kobaisi}, Mohammad and Craig, {Vincent S.J.} and Notley, {Shannon M.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

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doi = "10.1016/j.matchemphys.2017.11.012",

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AU - Quinn, Matthew D.J.

AU - Wang, Tao

AU - Al Kobaisi, Mohammad

AU - Craig, Vincent S.J.

AU - Notley, Shannon M.

PY - 2018/2/1

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N2 - Liquid exfoliated graphene sheets were incorporated within α-cyclodextrin-triblock copolymer supramolecular hydrogels prepared with a range of polyethylene oxide and polypropylene oxide block sizes and ratios allowing control over the release properties. The strong photothermal activity of graphene was employed to externally activate drug release from within the gels using near-infrared (NIR) irradiation. These supramolecular hybrid hydrogels showed thermoreversible changes in viscosity, which is necessary for an injectable, multiple release point drug delivery depot. This hybrid graphene-surfactant-α-CD gel system with thermoreversible properties is demonstrated herein to be externally NIR activated to induce controllable drug release.

AB - Liquid exfoliated graphene sheets were incorporated within α-cyclodextrin-triblock copolymer supramolecular hydrogels prepared with a range of polyethylene oxide and polypropylene oxide block sizes and ratios allowing control over the release properties. The strong photothermal activity of graphene was employed to externally activate drug release from within the gels using near-infrared (NIR) irradiation. These supramolecular hybrid hydrogels showed thermoreversible changes in viscosity, which is necessary for an injectable, multiple release point drug delivery depot. This hybrid graphene-surfactant-α-CD gel system with thermoreversible properties is demonstrated herein to be externally NIR activated to induce controllable drug release.

KW - 2D

KW - Drug release

KW - Graphene

KW - Hydrogel

KW - Near-infrared

KW - Photothermal

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U2 - 10.1016/j.matchemphys.2017.11.012

DO - 10.1016/j.matchemphys.2017.11.012

M3 - Article

SN - 0254-0584

VL - 205

SP - 154

EP - 163

JO - Materials Chemistry and Physics

JF - Materials Chemistry and Physics

ER -

PEO-PPO-PEO surfactant exfoliated graphene cyclodextrin drug carriers for photoresponsive release

Abstract

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