Peptide Ligation-Desulfurization Chemistry at Arginine

Lara R. Malins, Katie M. Cergol, Richard J. Payne*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)

Abstract

The utility of a new β-thiol arginine building block in ligation-desulfurization chemistry has been demonstrated through reactions and kinetic studies with a range of peptide thioesters. Application of the method is highlighted by a one-pot, kinetically controlled, rapid ligation to generate a 7 kDa MUC1 glycopeptide.

Original languageEnglish
Pages (from-to)559-563
Number of pages5
JournalChemBioChem
Volume14
Issue number5
Early online date20 Feb 2013
DOIs
Publication statusPublished - Mar 2013
Externally publishedYes

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