Abstract
The utility of a new β-thiol arginine building block in ligation-desulfurization chemistry has been demonstrated through reactions and kinetic studies with a range of peptide thioesters. Application of the method is highlighted by a one-pot, kinetically controlled, rapid ligation to generate a 7 kDa MUC1 glycopeptide.
Original language | English |
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Pages (from-to) | 559-563 |
Number of pages | 5 |
Journal | ChemBioChem |
Volume | 14 |
Issue number | 5 |
Early online date | 20 Feb 2013 |
DOIs | |
Publication status | Published - Mar 2013 |
Externally published | Yes |