Peptide Ligation-Desulfurization Chemistry at Arginine

Lara R. Malins; Katie M. Cergol; Richard J. Payne

doi:10.1002/cbic.201300049

Peptide Ligation-Desulfurization Chemistry at Arginine

Lara R. Malins, Katie M. Cergol, Richard J. Payne^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

The utility of a new β-thiol arginine building block in ligation-desulfurization chemistry has been demonstrated through reactions and kinetic studies with a range of peptide thioesters. Application of the method is highlighted by a one-pot, kinetically controlled, rapid ligation to generate a 7 kDa MUC1 glycopeptide.

Original language	English
Pages (from-to)	559-563
Number of pages	5
Journal	ChemBioChem
Volume	14
Issue number	5
Early online date	20 Feb 2013
DOIs	https://doi.org/10.1002/cbic.201300049
Publication status	Published - Mar 2013
Externally published	Yes

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10.1002/cbic.201300049

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title = "Peptide Ligation-Desulfurization Chemistry at Arginine",

abstract = "The utility of a new β-thiol arginine building block in ligation-desulfurization chemistry has been demonstrated through reactions and kinetic studies with a range of peptide thioesters. Application of the method is highlighted by a one-pot, kinetically controlled, rapid ligation to generate a 7 kDa MUC1 glycopeptide.",

keywords = "Arginine, Desulfurization, Glycopeptides, Ligation, Peptides",

author = "Malins, \{Lara R.\} and Cergol, \{Katie M.\} and Payne, \{Richard J.\}",

year = "2013",

month = mar,

doi = "10.1002/cbic.201300049",

language = "English",

volume = "14",

pages = "559--563",

journal = "ChemBioChem",

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T1 - Peptide Ligation-Desulfurization Chemistry at Arginine

AU - Malins, Lara R.

AU - Cergol, Katie M.

AU - Payne, Richard J.

PY - 2013/3

Y1 - 2013/3

N2 - The utility of a new β-thiol arginine building block in ligation-desulfurization chemistry has been demonstrated through reactions and kinetic studies with a range of peptide thioesters. Application of the method is highlighted by a one-pot, kinetically controlled, rapid ligation to generate a 7 kDa MUC1 glycopeptide.

AB - The utility of a new β-thiol arginine building block in ligation-desulfurization chemistry has been demonstrated through reactions and kinetic studies with a range of peptide thioesters. Application of the method is highlighted by a one-pot, kinetically controlled, rapid ligation to generate a 7 kDa MUC1 glycopeptide.

KW - Arginine

KW - Desulfurization

KW - Glycopeptides

KW - Ligation

KW - Peptides

UR - https://www.scopus.com/pages/publications/84875002264

U2 - 10.1002/cbic.201300049

DO - 10.1002/cbic.201300049

M3 - Article

SN - 1439-4227

VL - 14

SP - 559

EP - 563

JO - ChemBioChem

JF - ChemBioChem

IS - 5

ER -

Peptide Ligation-Desulfurization Chemistry at Arginine

Abstract

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