Perforin is essential for control of ectromelia virus but not related poxviruses in mice

Arno Müllbacher; Ron Tha Hla; Crisan Museteanu; Markus M. Simon

doi:10.1128/jvi.73.2.1665-1667.1999

Perforin is essential for control of ectromelia virus but not related poxviruses in mice

Arno Müllbacher^*, Ron Tha Hla, Crisan Museteanu, Markus M. Simon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

Lack of perforin renders the relatively resistant mouse strain C57BL/6 highly susceptible to the natural mouse pathogen ectromelia virus, a cytopathic orthopoxvirus. This is indicated by increased mortality, elevated virus titers and pathology in liver and spleen, and increased levels of liver enzymes in blood. Cowpox virus on the other hand is more virulent in the presence of perforin than in its absence. An additional lack of granzyme A which together with perforin is a constituent of cytoplasmic granules from cytotoxic T cells increases the virulence of cowpox virus.

Original language	English
Pages (from-to)	1665-1667
Number of pages	3
Journal	Journal of Virology
Volume	73
Issue number	2
DOIs	https://doi.org/10.1128/jvi.73.2.1665-1667.1999
Publication status	Published - 1999

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10.1128/jvi.73.2.1665-1667.1999

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title = "Perforin is essential for control of ectromelia virus but not related poxviruses in mice",

abstract = "Lack of perforin renders the relatively resistant mouse strain C57BL/6 highly susceptible to the natural mouse pathogen ectromelia virus, a cytopathic orthopoxvirus. This is indicated by increased mortality, elevated virus titers and pathology in liver and spleen, and increased levels of liver enzymes in blood. Cowpox virus on the other hand is more virulent in the presence of perforin than in its absence. An additional lack of granzyme A which together with perforin is a constituent of cytoplasmic granules from cytotoxic T cells increases the virulence of cowpox virus.",

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AU - Museteanu, Crisan

AU - Simon, Markus M.

PY - 1999

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AB - Lack of perforin renders the relatively resistant mouse strain C57BL/6 highly susceptible to the natural mouse pathogen ectromelia virus, a cytopathic orthopoxvirus. This is indicated by increased mortality, elevated virus titers and pathology in liver and spleen, and increased levels of liver enzymes in blood. Cowpox virus on the other hand is more virulent in the presence of perforin than in its absence. An additional lack of granzyme A which together with perforin is a constituent of cytoplasmic granules from cytotoxic T cells increases the virulence of cowpox virus.

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DO - 10.1128/jvi.73.2.1665-1667.1999

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JF - Journal of Virology

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ER -

Perforin is essential for control of ectromelia virus but not related poxviruses in mice

Abstract

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