Permeation dynamics of chloride ions in the ClC-0 and ClC-1 channels

Ben Corry; Megan O'Mara; Shin Ho Chung

doi:10.1016/j.cplett.2004.01.072

Permeation dynamics of chloride ions in the ClC-0 and ClC-1 channels

Ben Corry^*, Megan O'Mara, Shin Ho Chung

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We examine the mechanisms underlying the transport of ions across ClC-0 and ClC-1, the two best characterized members of the ubiquitous ClC chloride channel family. Using molecular and Brownian dynamics techniques we create an open channel structure, deduce the permeation characteristics, and highlight the amino acid residues responsible for the different conductance properties of these channels.

Original language	English
Pages (from-to)	233-238
Number of pages	6
Journal	Chemical Physics Letters
Volume	386
Issue number	4-6
DOIs	https://doi.org/10.1016/j.cplett.2004.01.072
Publication status	Published - 11 Mar 2004

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10.1016/j.cplett.2004.01.072

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title = "Permeation dynamics of chloride ions in the ClC-0 and ClC-1 channels",

abstract = "We examine the mechanisms underlying the transport of ions across ClC-0 and ClC-1, the two best characterized members of the ubiquitous ClC chloride channel family. Using molecular and Brownian dynamics techniques we create an open channel structure, deduce the permeation characteristics, and highlight the amino acid residues responsible for the different conductance properties of these channels.",

author = "Ben Corry and Megan O'Mara and Chung, {Shin Ho}",

year = "2004",

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doi = "10.1016/j.cplett.2004.01.072",

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T1 - Permeation dynamics of chloride ions in the ClC-0 and ClC-1 channels

AU - Corry, Ben

AU - O'Mara, Megan

AU - Chung, Shin Ho

PY - 2004/3/11

Y1 - 2004/3/11

N2 - We examine the mechanisms underlying the transport of ions across ClC-0 and ClC-1, the two best characterized members of the ubiquitous ClC chloride channel family. Using molecular and Brownian dynamics techniques we create an open channel structure, deduce the permeation characteristics, and highlight the amino acid residues responsible for the different conductance properties of these channels.

AB - We examine the mechanisms underlying the transport of ions across ClC-0 and ClC-1, the two best characterized members of the ubiquitous ClC chloride channel family. Using molecular and Brownian dynamics techniques we create an open channel structure, deduce the permeation characteristics, and highlight the amino acid residues responsible for the different conductance properties of these channels.

UR - http://www.scopus.com/inward/record.url?scp=1442360876&partnerID=8YFLogxK

U2 - 10.1016/j.cplett.2004.01.072

DO - 10.1016/j.cplett.2004.01.072

M3 - Article

SN - 0009-2614

VL - 386

SP - 233

EP - 238

JO - Chemical Physics Letters

JF - Chemical Physics Letters

IS - 4-6

ER -

Permeation dynamics of chloride ions in the ClC-0 and ClC-1 channels

Abstract

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