Peroxynitrite: A biologically significant oxidant

Michael P. Murphy; Michael A. Packer; Jared L. Scarlett; Stephen W. Martin

doi:10.1016/S0306-3623(97)00418-7

Peroxynitrite: A biologically significant oxidant

Michael P. Murphy^*, Michael A. Packer, Jared L. Scarlett, Stephen W. Martin

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

168 Citations (Scopus)

Abstract

1. Peroxynitrite is a short-lived and damaging oxidant that forms rapidly from the reaction of superoxide with nitric oxide. 2. In 1990, Joseph Beckman proposed that peroxynitrite contributed significantly to pathological oxidative stress in living tissues, and subsequent evidence strongly supports this proposal. 3. In this review, we outline the properties of peroxynitrite and discuss how it can affect biological systems and contribute to human pathologies.

Original language	English
Pages (from-to)	179-186
Number of pages	8
Journal	General Pharmacology
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/S0306-3623(97)00418-7
Publication status	Published - Aug 1998
Externally published	Yes

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title = "Peroxynitrite: A biologically significant oxidant",

abstract = "1. Peroxynitrite is a short-lived and damaging oxidant that forms rapidly from the reaction of superoxide with nitric oxide. 2. In 1990, Joseph Beckman proposed that peroxynitrite contributed significantly to pathological oxidative stress in living tissues, and subsequent evidence strongly supports this proposal. 3. In this review, we outline the properties of peroxynitrite and discuss how it can affect biological systems and contribute to human pathologies.",

keywords = "Nitric oxide, Oxidative stress, Peroxynitrite, Superoxide",

author = "Murphy, {Michael P.} and Packer, {Michael A.} and Scarlett, {Jared L.} and Martin, {Stephen W.}",

year = "1998",

month = aug,

doi = "10.1016/S0306-3623(97)00418-7",

language = "English",

volume = "31",

pages = "179--186",

journal = "General Pharmacology",

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T1 - Peroxynitrite

T2 - A biologically significant oxidant

AU - Murphy, Michael P.

AU - Packer, Michael A.

AU - Scarlett, Jared L.

AU - Martin, Stephen W.

PY - 1998/8

Y1 - 1998/8

N2 - 1. Peroxynitrite is a short-lived and damaging oxidant that forms rapidly from the reaction of superoxide with nitric oxide. 2. In 1990, Joseph Beckman proposed that peroxynitrite contributed significantly to pathological oxidative stress in living tissues, and subsequent evidence strongly supports this proposal. 3. In this review, we outline the properties of peroxynitrite and discuss how it can affect biological systems and contribute to human pathologies.

AB - 1. Peroxynitrite is a short-lived and damaging oxidant that forms rapidly from the reaction of superoxide with nitric oxide. 2. In 1990, Joseph Beckman proposed that peroxynitrite contributed significantly to pathological oxidative stress in living tissues, and subsequent evidence strongly supports this proposal. 3. In this review, we outline the properties of peroxynitrite and discuss how it can affect biological systems and contribute to human pathologies.

KW - Nitric oxide

KW - Oxidative stress

KW - Peroxynitrite

KW - Superoxide

UR - http://www.scopus.com/inward/record.url?scp=0031837496&partnerID=8YFLogxK

U2 - 10.1016/S0306-3623(97)00418-7

DO - 10.1016/S0306-3623(97)00418-7

M3 - Review article

C2 - 9688457

AN - SCOPUS:0031837496

SN - 0306-3623

VL - 31

SP - 179

EP - 186

JO - General Pharmacology

JF - General Pharmacology

IS - 2

ER -

Peroxynitrite: A biologically significant oxidant

Abstract

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