Pesticides and Parkinson's disease

D. G. Le Couteur; A. J. McLean; M. C. Taylor; B. L. Woodham; P. G. Board

doi:10.1016/S0753-3322(99)80077-8

Pesticides and Parkinson's disease

D. G. Le Couteur^*, A. J. McLean, M. C. Taylor, B. L. Woodham, P. G. Board

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

188 Citations (Scopus)

Abstract

Epidemiological studies and case reports provide evidence for an association between Parkinson's disease and past exposure to pesticides. Susceptibility to the effects of pesticides and other putative neurotoxins depends on variability in xenobiotic metabolism possibly generated by genetic polymorphisms, aging and variation in exposure to environmental agents including pesticides. The simplest mechanistic hypothesis for the association of pesticides with Parkinson's disease is that pesticides or their metabolites are directly toxic to mitochondria, although modulation of xenobiotic metabolism by pesticides provides an adjunct or alternative hypothesis.

Original language	English
Pages (from-to)	122-130
Number of pages	9
Journal	Biomedicine and Pharmacotherapy
Volume	53
Issue number	3
DOIs	https://doi.org/10.1016/S0753-3322(99)80077-8
Publication status	Published - Apr 1999

Access to Document

10.1016/S0753-3322(99)80077-8

Cite this

@article{67ef5279e05f4b2fbde6d3ed74b37bff,

title = "Pesticides and Parkinson's disease",

abstract = "Epidemiological studies and case reports provide evidence for an association between Parkinson's disease and past exposure to pesticides. Susceptibility to the effects of pesticides and other putative neurotoxins depends on variability in xenobiotic metabolism possibly generated by genetic polymorphisms, aging and variation in exposure to environmental agents including pesticides. The simplest mechanistic hypothesis for the association of pesticides with Parkinson's disease is that pesticides or their metabolites are directly toxic to mitochondria, although modulation of xenobiotic metabolism by pesticides provides an adjunct or alternative hypothesis.",

keywords = "Aging, Parkinson's disease, Pesticide",

author = "{Le Couteur}, {D. G.} and McLean, {A. J.} and Taylor, {M. C.} and Woodham, {B. L.} and Board, {P. G.}",

year = "1999",

month = apr,

doi = "10.1016/S0753-3322(99)80077-8",

language = "English",

volume = "53",

pages = "122--130",

journal = "Biomedicine and Pharmacotherapy",

issn = "0753-3322",

publisher = "Elsevier Masson s.r.l.",

number = "3",

}

TY - JOUR

T1 - Pesticides and Parkinson's disease

AU - Le Couteur, D. G.

AU - McLean, A. J.

AU - Taylor, M. C.

AU - Woodham, B. L.

AU - Board, P. G.

PY - 1999/4

Y1 - 1999/4

N2 - Epidemiological studies and case reports provide evidence for an association between Parkinson's disease and past exposure to pesticides. Susceptibility to the effects of pesticides and other putative neurotoxins depends on variability in xenobiotic metabolism possibly generated by genetic polymorphisms, aging and variation in exposure to environmental agents including pesticides. The simplest mechanistic hypothesis for the association of pesticides with Parkinson's disease is that pesticides or their metabolites are directly toxic to mitochondria, although modulation of xenobiotic metabolism by pesticides provides an adjunct or alternative hypothesis.

AB - Epidemiological studies and case reports provide evidence for an association between Parkinson's disease and past exposure to pesticides. Susceptibility to the effects of pesticides and other putative neurotoxins depends on variability in xenobiotic metabolism possibly generated by genetic polymorphisms, aging and variation in exposure to environmental agents including pesticides. The simplest mechanistic hypothesis for the association of pesticides with Parkinson's disease is that pesticides or their metabolites are directly toxic to mitochondria, although modulation of xenobiotic metabolism by pesticides provides an adjunct or alternative hypothesis.

KW - Aging

KW - Parkinson's disease

KW - Pesticide

UR - http://www.scopus.com/inward/record.url?scp=0033117146&partnerID=8YFLogxK

U2 - 10.1016/S0753-3322(99)80077-8

DO - 10.1016/S0753-3322(99)80077-8

M3 - Article

SN - 0753-3322

VL - 53

SP - 122

EP - 130

JO - Biomedicine and Pharmacotherapy

JF - Biomedicine and Pharmacotherapy

IS - 3

ER -

Pesticides and Parkinson's disease

Abstract

Access to Document

Other files and links

Fingerprint

Cite this