Pesticides and Parkinson's disease

D. G. Le Couteur*, A. J. McLean, M. C. Taylor, B. L. Woodham, P. G. Board

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    187 Citations (Scopus)

    Abstract

    Epidemiological studies and case reports provide evidence for an association between Parkinson's disease and past exposure to pesticides. Susceptibility to the effects of pesticides and other putative neurotoxins depends on variability in xenobiotic metabolism possibly generated by genetic polymorphisms, aging and variation in exposure to environmental agents including pesticides. The simplest mechanistic hypothesis for the association of pesticides with Parkinson's disease is that pesticides or their metabolites are directly toxic to mitochondria, although modulation of xenobiotic metabolism by pesticides provides an adjunct or alternative hypothesis.

    Original languageEnglish
    Pages (from-to)122-130
    Number of pages9
    JournalBiomedicine and Pharmacotherapy
    Volume53
    Issue number3
    DOIs
    Publication statusPublished - Apr 1999

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