PH-responsive fluorescent hydrogels using a new thioflavin T cross-linker

Zeyun Xiao, Ross Andrew Lennox Wylie, Emma Ruth Lucille Brisson, Luke Andrew Connal*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Thioflavin T has been frequently used as a fluorescence sensor for a series of neurodegenerative diseases, biomolecules, and metal ions. Here, a simple covalently linked thioflavin T analog endows pH-responsive characteristic to the polyethylene glycol hydrogels. The pH-dependent swelling ratio and fluorescence intensity provide two different outputs toward pH change making this system suitable for fluorescence monitored biomedical and analytical applications.

Original languageEnglish
Pages (from-to)591-595
Number of pages5
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume54
Issue number5
DOIs
Publication statusPublished - 1 Mar 2016
Externally publishedYes

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