PH-responsive fluorescent hydrogels using a new thioflavin T cross-linker

Zeyun Xiao; Ross Andrew Lennox Wylie; Emma Ruth Lucille Brisson; Luke Andrew Connal

doi:10.1002/pola.27974

PH-responsive fluorescent hydrogels using a new thioflavin T cross-linker

Zeyun Xiao
, Ross Andrew Lennox Wylie
, Emma Ruth Lucille Brisson
, Luke Andrew Connal^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Thioflavin T has been frequently used as a fluorescence sensor for a series of neurodegenerative diseases, biomolecules, and metal ions. Here, a simple covalently linked thioflavin T analog endows pH-responsive characteristic to the polyethylene glycol hydrogels. The pH-dependent swelling ratio and fluorescence intensity provide two different outputs toward pH change making this system suitable for fluorescence monitored biomedical and analytical applications.

Original language	English
Pages (from-to)	591-595
Number of pages	5
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	54
Issue number	5
DOIs	https://doi.org/10.1002/pola.27974
Publication status	Published - 1 Mar 2016
Externally published	Yes

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10.1002/pola.27974

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title = "PH-responsive fluorescent hydrogels using a new thioflavin T cross-linker",

abstract = "Thioflavin T has been frequently used as a fluorescence sensor for a series of neurodegenerative diseases, biomolecules, and metal ions. Here, a simple covalently linked thioflavin T analog endows pH-responsive characteristic to the polyethylene glycol hydrogels. The pH-dependent swelling ratio and fluorescence intensity provide two different outputs toward pH change making this system suitable for fluorescence monitored biomedical and analytical applications.",

keywords = "crosslinking, functionalization of polymers, hydrogels, pH-responsive polymers, poly(ethylene glycol), stimuli-sensitive polymers",

author = "Zeyun Xiao and Wylie, \{Ross Andrew Lennox\} and Brisson, \{Emma Ruth Lucille\} and Connal, \{Luke Andrew\}",

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T1 - PH-responsive fluorescent hydrogels using a new thioflavin T cross-linker

AU - Xiao, Zeyun

AU - Wylie, Ross Andrew Lennox

AU - Brisson, Emma Ruth Lucille

AU - Connal, Luke Andrew

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Thioflavin T has been frequently used as a fluorescence sensor for a series of neurodegenerative diseases, biomolecules, and metal ions. Here, a simple covalently linked thioflavin T analog endows pH-responsive characteristic to the polyethylene glycol hydrogels. The pH-dependent swelling ratio and fluorescence intensity provide two different outputs toward pH change making this system suitable for fluorescence monitored biomedical and analytical applications.

AB - Thioflavin T has been frequently used as a fluorescence sensor for a series of neurodegenerative diseases, biomolecules, and metal ions. Here, a simple covalently linked thioflavin T analog endows pH-responsive characteristic to the polyethylene glycol hydrogels. The pH-dependent swelling ratio and fluorescence intensity provide two different outputs toward pH change making this system suitable for fluorescence monitored biomedical and analytical applications.

KW - crosslinking

KW - functionalization of polymers

KW - hydrogels

KW - pH-responsive polymers

KW - poly(ethylene glycol)

KW - stimuli-sensitive polymers

UR - https://www.scopus.com/pages/publications/84957021832

U2 - 10.1002/pola.27974

DO - 10.1002/pola.27974

M3 - Article

SN - 0887-624X

VL - 54

SP - 591

EP - 595

JO - Journal of Polymer Science, Part A: Polymer Chemistry

JF - Journal of Polymer Science, Part A: Polymer Chemistry

IS - 5

ER -

PH-responsive fluorescent hydrogels using a new thioflavin T cross-linker

Abstract

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