Phenomics of the laboratory mouse

Using model organisms to study human disease has many benefi ts for the experimental scientist. Primary amongst these is the ability to carry out experimental manipulations, an approach not possible in humans. Because of their relatively close phylogenetic relationships to man and consequently their more similar physiology and development, mammals are the most popular group used as models of human disease. Other organisms, most notably zebrafi sh (Danio rerio; see Chapter 4 of this book), fruit fl y (Drosophila melanogaster) and nematode worm (Caenorhabditis elegans), are also used and can provide useful insights.