Phytochemical and pharmacological studies on four Indonesian epiphytic medicinal plants: Drynaria rigidula, Hydnophytum formicarum, Usnea misaminensis, and Calymperes schmidtii

Ari S. Nugraha; Tashi Wangchuk; Anthony C. Willis; Rachada Haritakun; Heri Sujadmiko; Paul A. Keller

doi:10.1177/1934578X19856792

Phytochemical and pharmacological studies on four Indonesian epiphytic medicinal plants: Drynaria rigidula, Hydnophytum formicarum, Usnea misaminensis, and Calymperes schmidtii

Ari S. Nugraha
, Tashi Wangchuk
, Anthony C. Willis
, Rachada Haritakun
, Heri Sujadmiko
, Paul A. Keller^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Phytochemical studies performed on 4 Indonesian epiphytic medicinal plants, Drynaria rigidula L., Hydnophytum formicarum Jack, Usnea misaminensis (Vain) Motyka, and Calymperes schmidtii Broth., revealed 11 known secondary metabolites (1-11), reported from these species for the first time. The methanol extracts and their fractions were screened against infective agents and cancer cells. The dichloromethane fractions of H. formicarum, U. misaminensis, and C. schmidtii showed activity against lung cancer cells with IC₅₀ values of 35, 11, and 20 µg/mL, respectively.

Original language	English
Journal	Natural Product Communications
Volume	14
Issue number	6
DOIs	https://doi.org/10.1177/1934578X19856792
Publication status	Published - Jun 2019

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title = "Phytochemical and pharmacological studies on four Indonesian epiphytic medicinal plants: Drynaria rigidula, Hydnophytum formicarum, Usnea misaminensis, and Calymperes schmidtii",

abstract = "Phytochemical studies performed on 4 Indonesian epiphytic medicinal plants, Drynaria rigidula L., Hydnophytum formicarum Jack, Usnea misaminensis (Vain) Motyka, and Calymperes schmidtii Broth., revealed 11 known secondary metabolites (1-11), reported from these species for the first time. The methanol extracts and their fractions were screened against infective agents and cancer cells. The dichloromethane fractions of H. formicarum, U. misaminensis, and C. schmidtii showed activity against lung cancer cells with IC50 values of 35, 11, and 20 µg/mL, respectively.",

keywords = "Calymperes schmidtii, Drynaria rigidula, Epiphytes, Hydnophytum formicarum, Indonesian medicinal plant, Isolation, Usnea misaminensis",

author = "Nugraha, \{Ari S.\} and Tashi Wangchuk and Willis, \{Anthony C.\} and Rachada Haritakun and Heri Sujadmiko and Keller, \{Paul A.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2019.",

year = "2019",

month = jun,

doi = "10.1177/1934578X19856792",

language = "English",

volume = "14",

journal = "Natural Product Communications",

issn = "1934-578X",

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TY - JOUR

T1 - Phytochemical and pharmacological studies on four Indonesian epiphytic medicinal plants

T2 - Drynaria rigidula, Hydnophytum formicarum, Usnea misaminensis, and Calymperes schmidtii

AU - Nugraha, Ari S.

AU - Wangchuk, Tashi

AU - Willis, Anthony C.

AU - Haritakun, Rachada

AU - Sujadmiko, Heri

AU - Keller, Paul A.

N1 - Publisher Copyright: © The Author(s) 2019.

PY - 2019/6

Y1 - 2019/6

N2 - Phytochemical studies performed on 4 Indonesian epiphytic medicinal plants, Drynaria rigidula L., Hydnophytum formicarum Jack, Usnea misaminensis (Vain) Motyka, and Calymperes schmidtii Broth., revealed 11 known secondary metabolites (1-11), reported from these species for the first time. The methanol extracts and their fractions were screened against infective agents and cancer cells. The dichloromethane fractions of H. formicarum, U. misaminensis, and C. schmidtii showed activity against lung cancer cells with IC50 values of 35, 11, and 20 µg/mL, respectively.

AB - Phytochemical studies performed on 4 Indonesian epiphytic medicinal plants, Drynaria rigidula L., Hydnophytum formicarum Jack, Usnea misaminensis (Vain) Motyka, and Calymperes schmidtii Broth., revealed 11 known secondary metabolites (1-11), reported from these species for the first time. The methanol extracts and their fractions were screened against infective agents and cancer cells. The dichloromethane fractions of H. formicarum, U. misaminensis, and C. schmidtii showed activity against lung cancer cells with IC50 values of 35, 11, and 20 µg/mL, respectively.

KW - Calymperes schmidtii

KW - Drynaria rigidula

KW - Epiphytes

KW - Hydnophytum formicarum

KW - Indonesian medicinal plant

KW - Isolation

KW - Usnea misaminensis

UR - https://www.scopus.com/pages/publications/85067396647

U2 - 10.1177/1934578X19856792

DO - 10.1177/1934578X19856792

M3 - Article

SN - 1934-578X

VL - 14

JO - Natural Product Communications

JF - Natural Product Communications

IS - 6

ER -

Phytochemical and pharmacological studies on four Indonesian epiphytic medicinal plants: Drynaria rigidula, Hydnophytum formicarum, Usnea misaminensis, and Calymperes schmidtii

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