Plasmin activates VEGF-C and VEGF-D

Bradley K. McColl; Megan E. Baldwin; Sally Roufail; Craig Freeman; Kari Alitalo; Steven A. Stacker; Marc G. Achen

doi:10.1016/j.ics.2003.11.032

Plasmin activates VEGF-C and VEGF-D

Bradley K. McColl, Megan E. Baldwin, Sally Roufail, Craig Freeman, Kari Alitalo, Steven A. Stacker, Marc G. Achen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Angiogenesis and lymphangiogenesis (growth of lymphatic vessels) are guided by members of the vascular endothelial growth factor (VEGF) family of secreted glycoproteins. In particular, VEGF-C and VEGF-D promote lymphangiogenesis as demonstrated in transgenic animal models and gene delivery studies. VEGF-C and VEGF-D are secreted as full-length forms that require proteolytic activation for high affinity binding to VEGF receptor-2 (VEGFR-2) and VEGFR-3, cell surface receptor tyrosine kinases localised on the endothelial cells of blood vessels and lymphatics. The proteases that activate these lymphangiogenic growth factors are key regulators of lymphatic development but were previously unknown. Here we report identification of the serine protease plasmin as an enzyme capable of activating both VEGF-C and VEGF-D.

Original language	English
Pages (from-to)	79-82
Number of pages	4
Journal	International Congress Series
Volume	1262
DOIs	https://doi.org/10.1016/j.ics.2003.11.032
Publication status	Published - 1 May 2004

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title = "Plasmin activates VEGF-C and VEGF-D",

abstract = "Angiogenesis and lymphangiogenesis (growth of lymphatic vessels) are guided by members of the vascular endothelial growth factor (VEGF) family of secreted glycoproteins. In particular, VEGF-C and VEGF-D promote lymphangiogenesis as demonstrated in transgenic animal models and gene delivery studies. VEGF-C and VEGF-D are secreted as full-length forms that require proteolytic activation for high affinity binding to VEGF receptor-2 (VEGFR-2) and VEGFR-3, cell surface receptor tyrosine kinases localised on the endothelial cells of blood vessels and lymphatics. The proteases that activate these lymphangiogenic growth factors are key regulators of lymphatic development but were previously unknown. Here we report identification of the serine protease plasmin as an enzyme capable of activating both VEGF-C and VEGF-D.",

keywords = "Growth factor, Lymphangiogenesis, Lymphatics, Metastasis, Proteolysis",

author = "McColl, {Bradley K.} and Baldwin, {Megan E.} and Sally Roufail and Craig Freeman and Kari Alitalo and Stacker, {Steven A.} and Achen, {Marc G.}",

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doi = "10.1016/j.ics.2003.11.032",

language = "English",

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T1 - Plasmin activates VEGF-C and VEGF-D

AU - McColl, Bradley K.

AU - Baldwin, Megan E.

AU - Roufail, Sally

AU - Freeman, Craig

AU - Alitalo, Kari

AU - Stacker, Steven A.

AU - Achen, Marc G.

PY - 2004/5/1

Y1 - 2004/5/1

N2 - Angiogenesis and lymphangiogenesis (growth of lymphatic vessels) are guided by members of the vascular endothelial growth factor (VEGF) family of secreted glycoproteins. In particular, VEGF-C and VEGF-D promote lymphangiogenesis as demonstrated in transgenic animal models and gene delivery studies. VEGF-C and VEGF-D are secreted as full-length forms that require proteolytic activation for high affinity binding to VEGF receptor-2 (VEGFR-2) and VEGFR-3, cell surface receptor tyrosine kinases localised on the endothelial cells of blood vessels and lymphatics. The proteases that activate these lymphangiogenic growth factors are key regulators of lymphatic development but were previously unknown. Here we report identification of the serine protease plasmin as an enzyme capable of activating both VEGF-C and VEGF-D.

AB - Angiogenesis and lymphangiogenesis (growth of lymphatic vessels) are guided by members of the vascular endothelial growth factor (VEGF) family of secreted glycoproteins. In particular, VEGF-C and VEGF-D promote lymphangiogenesis as demonstrated in transgenic animal models and gene delivery studies. VEGF-C and VEGF-D are secreted as full-length forms that require proteolytic activation for high affinity binding to VEGF receptor-2 (VEGFR-2) and VEGFR-3, cell surface receptor tyrosine kinases localised on the endothelial cells of blood vessels and lymphatics. The proteases that activate these lymphangiogenic growth factors are key regulators of lymphatic development but were previously unknown. Here we report identification of the serine protease plasmin as an enzyme capable of activating both VEGF-C and VEGF-D.

KW - Growth factor

KW - Lymphangiogenesis

KW - Lymphatics

KW - Metastasis

KW - Proteolysis

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U2 - 10.1016/j.ics.2003.11.032

DO - 10.1016/j.ics.2003.11.032

M3 - Article

SN - 0531-5131

VL - 1262

SP - 79

EP - 82

JO - International Congress Series

JF - International Congress Series

ER -

Plasmin activates VEGF-C and VEGF-D

Abstract

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