TY - JOUR
T1 - Plasmodium permeomics
T2 - Membrane transport proteins in the malaria parasite
AU - Kirk, Kiaran
AU - Martin, R. E.
AU - Bröer, S.
AU - Howitt, S. M.
AU - Saliba, K. J.
PY - 2005
Y1 - 2005
N2 - Membrane transport proteins are integral membrane proteins that mediate the passage across the membrane bilayer of specific molecules and/or ions. Such proteins serve a diverse range of physiological roles, mediating the uptake of nutrients into cells, the removal of metabolic wastes and xenobiotics (including drugs), and the generation and maintenance of transmembrane electrochemical gradients. In this chapter we review the present state of knowledge of the membrane transport mechanisms underlying the cell physiology of the intraerythrocytic malaria parasite and its host cell, considering in particular physiological measurements on the parasite and parasitized erythrocyte, the annotation of transport proteins in the Plasmodium genome, and molecular methods used to analyze transport protein function.
AB - Membrane transport proteins are integral membrane proteins that mediate the passage across the membrane bilayer of specific molecules and/or ions. Such proteins serve a diverse range of physiological roles, mediating the uptake of nutrients into cells, the removal of metabolic wastes and xenobiotics (including drugs), and the generation and maintenance of transmembrane electrochemical gradients. In this chapter we review the present state of knowledge of the membrane transport mechanisms underlying the cell physiology of the intraerythrocytic malaria parasite and its host cell, considering in particular physiological measurements on the parasite and parasitized erythrocyte, the annotation of transport proteins in the Plasmodium genome, and molecular methods used to analyze transport protein function.
UR - http://www.scopus.com/inward/record.url?scp=24144442901&partnerID=8YFLogxK
U2 - 10.1007/3-540-29088-5_13
DO - 10.1007/3-540-29088-5_13
M3 - Review article
SN - 0070-217X
VL - 295
SP - 325
EP - 356
JO - Current Topics in Microbiology and Immunology
JF - Current Topics in Microbiology and Immunology
ER -