Platelets in malarial infection: Protective or pathological?

Simon Foote; Gaétan Burgio; Brendan McMorran

doi:10.1007/978-3-319-47462-5_73

Platelets in malarial infection: Protective or pathological?

Simon Foote^*, Gaétan Burgio, Brendan McMorran

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

Platelets play an ambiguous role in a malarial infection. On the one hand, platelets have been implicated adversely in cerebral malaria. They stick to the cerebral endothelium and mediate the adhesion of infected erythrocytes, with the postulated outcome of increasing severity or of even mediating this disease. On the other hand, platelets bind to infected red cells in the periphery and activate and release the cytokine PF4. This, in turn, binds to the Duffy antigen on the red cell and is thought to be internalised and enters the parasite food vacuole which it then destroys, killing the parasites. The control of platelet levels during an infection is also discussed with a view to understanding the thrombocytopenia that frequently accompanies a malarial infection.

Original language	English
Title of host publication	Platelets in Thrombotic and Non-Thrombotic Disorders
Subtitle of host publication	Pathophysiology, Pharmacology and Therapeutics: an Update
Publisher	Springer International Publishing Switzerland
Pages	1103-1109
Number of pages	7
ISBN (Electronic)	9783319474625
ISBN (Print)	9783319474601
DOIs	https://doi.org/10.1007/978-3-319-47462-5_73
Publication status	Published - 8 Mar 2017

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10.1007/978-3-319-47462-5_73

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title = "Platelets in malarial infection: Protective or pathological?",

abstract = "Platelets play an ambiguous role in a malarial infection. On the one hand, platelets have been implicated adversely in cerebral malaria. They stick to the cerebral endothelium and mediate the adhesion of infected erythrocytes, with the postulated outcome of increasing severity or of even mediating this disease. On the other hand, platelets bind to infected red cells in the periphery and activate and release the cytokine PF4. This, in turn, binds to the Duffy antigen on the red cell and is thought to be internalised and enters the parasite food vacuole which it then destroys, killing the parasites. The control of platelet levels during an infection is also discussed with a view to understanding the thrombocytopenia that frequently accompanies a malarial infection.",

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Platelets in malarial infection: Protective or pathological? / Foote, Simon; Burgio, Gaétan ; McMorran, Brendan.
Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update. Springer International Publishing Switzerland, 2017. p. 1103-1109.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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Platelets in malarial infection: Protective or pathological?

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