TY - GEN
T1 - Point process respiratory sinus arrhythmia analysis during deep tissue pain stimulation
AU - Kodituwakku, Sandun
AU - Kim, Jieun
AU - Napadow, Vitaly
AU - Loggia, Marco L.
AU - Barbieri, Riccardo
PY - 2011
Y1 - 2011
N2 - We present an analysis of autonomic nervous system responses to deep tissue pain by using an instantaneous point process assessment of Heart Rate Variability (HRV) and Respiratory Sinus Arrhythmia (RSA). Ten subjects received pressure stimuli at 8 individually calibrated intensities (7 painful) over three separate runs. An inverse Gaussian point process framework modeled the R-R interval (RR) by defining a bivariate regression incorporating both past RRs and respiration values observed at the beats. Instantaneous indices of sympatho-vagal balance and RSA were estimated combining a maximum-likelihood algorithm with time-frequency analysis. The model was validated by Kolmogorov-Smirnov goodness-of-fit and independence tests. Results show that, in comparison to the resting period, all three pain runs elicited a significant decrease in RSA by over 21% (p=0.0547, 0.0234, 0.0547) indicating a reduced parasympathetic tone during pain, with RSA estimates negatively correlated with the calibrated stimulus intensity levels (slope = -0.4123, p=0.0633).
AB - We present an analysis of autonomic nervous system responses to deep tissue pain by using an instantaneous point process assessment of Heart Rate Variability (HRV) and Respiratory Sinus Arrhythmia (RSA). Ten subjects received pressure stimuli at 8 individually calibrated intensities (7 painful) over three separate runs. An inverse Gaussian point process framework modeled the R-R interval (RR) by defining a bivariate regression incorporating both past RRs and respiration values observed at the beats. Instantaneous indices of sympatho-vagal balance and RSA were estimated combining a maximum-likelihood algorithm with time-frequency analysis. The model was validated by Kolmogorov-Smirnov goodness-of-fit and independence tests. Results show that, in comparison to the resting period, all three pain runs elicited a significant decrease in RSA by over 21% (p=0.0547, 0.0234, 0.0547) indicating a reduced parasympathetic tone during pain, with RSA estimates negatively correlated with the calibrated stimulus intensity levels (slope = -0.4123, p=0.0633).
UR - http://www.scopus.com/inward/record.url?scp=84860008476&partnerID=8YFLogxK
M3 - Conference contribution
SN - 9781457706127
T3 - Computing in Cardiology
SP - 193
EP - 196
BT - Computing in Cardiology 2011, CinC 2011
T2 - Computing in Cardiology 2011, CinC 2011
Y2 - 18 September 2011 through 21 September 2011
ER -