Polymer End Group Control through a Decarboxylative Cobalt-Mediated Radical Polymerization: New Avenues for Synthesizing Peptide, Protein, and Nanomaterial Conjugates

Meri Ayurini, Peter G. Chandler, Paul D. O'Leary, Ruoxin Wang, David Rudd, Karen D. Milewska, Lara R. Malins, Ashley M. Buckle*, Joel F. Hooper*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Cobalt-mediated radical polymerizations (CMRPs) have been initiated by the radical decarboxylation of tetrachlorophthalimide activated esters. This allows for the controlled radical polymerization of activated monomers across a broad temperature range with a single cobalt species, with the incorporation of polymer end groups derived from simple carboxylic acid derivatives and termination with an organozinc reagent. This method has been applied to the synthesis of a polymer/graphene conjugate and a water-soluble protein/polymer conjugate, demonstrating the first examples of CMRP in graphene and protein conjugation.

Original languageEnglish
Pages (from-to)169-177
Number of pages9
JournalJACS Au
Volume2
Issue number1
DOIs
Publication statusPublished - 24 Jan 2022

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