Positive survival trend in metastatic head and neck cutaneous squamous cell carcinoma over four-decades: Multicenter study

Shaheen Hasmat; Ardalan Ebrahimi; Peter P. Luk; Tsu Hui Low; Lachlan McDowell; Matthew J.R. Magarey; Michael Veness; Ruta Gupta; Jonathan Clark

doi:10.1002/hed.25912

Positive survival trend in metastatic head and neck cutaneous squamous cell carcinoma over four-decades: Multicenter study

Shaheen Hasmat^*, Ardalan Ebrahimi, Peter P. Luk, Tsu Hui Low, Lachlan McDowell, Matthew J.R. Magarey, Michael Veness, Ruta Gupta, Jonathan Clark

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Background: This study assessed changes over time of survival of head and neck cutaneous squamous cell carcinoma (HNcSCC) with lymph node metastases. Methods: A multicenter analysis of 1301 patients with metastatic HNcSCC treated between 1980 and 2017. Differences in disease-specific survival (DSS) and overall survival (OS) by decade were assessed using multivariate Cox regression. Results: Over the study period, we noted an increase in the proportion of patients aged over 80 years (3.9%-31.7%; P <.001) and immunosuppression (1.9%-9.9%; P =.03). After adjusting for number and size of metastatic nodes, extranodal extension, perineural invasion, immunosuppression, treatment, and institution, there was a reduction in risk of cancer-related mortality from 0.47 in 1990-1999 (P =.04) to 0.30 in 2000-2009 (P <.001) when compared to 1980-1989. This remained stable at 0.30 in 2010-2017 (P =.001). OS remained stable after 1990. Conclusion: Despite an aging and more frequently immunosuppressed population, fewer patients are dying from metastatic HNcSCC.

Original language	English
Pages (from-to)	3826-3832
Number of pages	7
Journal	Head and Neck
Volume	41
Issue number	11
DOIs	https://doi.org/10.1002/hed.25912
Publication status	Published - 1 Nov 2019

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title = "Positive survival trend in metastatic head and neck cutaneous squamous cell carcinoma over four-decades: Multicenter study",

abstract = "Background: This study assessed changes over time of survival of head and neck cutaneous squamous cell carcinoma (HNcSCC) with lymph node metastases. Methods: A multicenter analysis of 1301 patients with metastatic HNcSCC treated between 1980 and 2017. Differences in disease-specific survival (DSS) and overall survival (OS) by decade were assessed using multivariate Cox regression. Results: Over the study period, we noted an increase in the proportion of patients aged over 80 years (3.9%-31.7%; P <.001) and immunosuppression (1.9%-9.9%; P =.03). After adjusting for number and size of metastatic nodes, extranodal extension, perineural invasion, immunosuppression, treatment, and institution, there was a reduction in risk of cancer-related mortality from 0.47 in 1990-1999 (P =.04) to 0.30 in 2000-2009 (P <.001) when compared to 1980-1989. This remained stable at 0.30 in 2010-2017 (P =.001). OS remained stable after 1990. Conclusion: Despite an aging and more frequently immunosuppressed population, fewer patients are dying from metastatic HNcSCC.",

keywords = "carcinoma, chemoradiation, head and neck, surgery, survival",

author = "Shaheen Hasmat and Ardalan Ebrahimi and Luk, {Peter P.} and Low, {Tsu Hui} and Lachlan McDowell and Magarey, {Matthew J.R.} and Michael Veness and Ruta Gupta and Jonathan Clark",

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doi = "10.1002/hed.25912",

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T1 - Positive survival trend in metastatic head and neck cutaneous squamous cell carcinoma over four-decades

T2 - Multicenter study

AU - Hasmat, Shaheen

AU - Ebrahimi, Ardalan

AU - Luk, Peter P.

AU - Low, Tsu Hui

AU - McDowell, Lachlan

AU - Magarey, Matthew J.R.

AU - Veness, Michael

AU - Gupta, Ruta

AU - Clark, Jonathan

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Background: This study assessed changes over time of survival of head and neck cutaneous squamous cell carcinoma (HNcSCC) with lymph node metastases. Methods: A multicenter analysis of 1301 patients with metastatic HNcSCC treated between 1980 and 2017. Differences in disease-specific survival (DSS) and overall survival (OS) by decade were assessed using multivariate Cox regression. Results: Over the study period, we noted an increase in the proportion of patients aged over 80 years (3.9%-31.7%; P <.001) and immunosuppression (1.9%-9.9%; P =.03). After adjusting for number and size of metastatic nodes, extranodal extension, perineural invasion, immunosuppression, treatment, and institution, there was a reduction in risk of cancer-related mortality from 0.47 in 1990-1999 (P =.04) to 0.30 in 2000-2009 (P <.001) when compared to 1980-1989. This remained stable at 0.30 in 2010-2017 (P =.001). OS remained stable after 1990. Conclusion: Despite an aging and more frequently immunosuppressed population, fewer patients are dying from metastatic HNcSCC.

AB - Background: This study assessed changes over time of survival of head and neck cutaneous squamous cell carcinoma (HNcSCC) with lymph node metastases. Methods: A multicenter analysis of 1301 patients with metastatic HNcSCC treated between 1980 and 2017. Differences in disease-specific survival (DSS) and overall survival (OS) by decade were assessed using multivariate Cox regression. Results: Over the study period, we noted an increase in the proportion of patients aged over 80 years (3.9%-31.7%; P <.001) and immunosuppression (1.9%-9.9%; P =.03). After adjusting for number and size of metastatic nodes, extranodal extension, perineural invasion, immunosuppression, treatment, and institution, there was a reduction in risk of cancer-related mortality from 0.47 in 1990-1999 (P =.04) to 0.30 in 2000-2009 (P <.001) when compared to 1980-1989. This remained stable at 0.30 in 2010-2017 (P =.001). OS remained stable after 1990. Conclusion: Despite an aging and more frequently immunosuppressed population, fewer patients are dying from metastatic HNcSCC.

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KW - chemoradiation

KW - head and neck

KW - surgery

KW - survival

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DO - 10.1002/hed.25912

M3 - Article

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EP - 3832

JO - Head and Neck

JF - Head and Neck

IS - 11

ER -

Positive survival trend in metastatic head and neck cutaneous squamous cell carcinoma over four-decades: Multicenter study

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