Potent and selective inhibitors of human peptidylglycine α-amidating monooxygenase

Feihua Cao; Allan B. Gamble; Hye Kyung Kim; Hideki Onagi; Mary J. Gresser; Jamie Kerr; Christopher J. Easton

doi:10.1039/c1md00079a

Potent and selective inhibitors of human peptidylglycine α-amidating monooxygenase

Feihua Cao, Allan B. Gamble, Hye Kyung Kim, Hideki Onagi, Mary J. Gresser, Jamie Kerr, Christopher J. Easton^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Fatty acid glycolates are nanomolar inhibitors of small cell lung carcinoma peptidylglycine α-amidating monooxygenase, with binding affinities orders of magnitude stronger than those of the analogous thioesters, the corresponding substrate glycine derivatives or the natural substrate procalcitonin.

Original language	English
Pages (from-to)	760-763
Number of pages	4
Journal	MedChemComm
Volume	2
Issue number	8
DOIs	https://doi.org/10.1039/c1md00079a
Publication status	Published - Aug 2011

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title = "Potent and selective inhibitors of human peptidylglycine α-amidating monooxygenase",

abstract = "Fatty acid glycolates are nanomolar inhibitors of small cell lung carcinoma peptidylglycine α-amidating monooxygenase, with binding affinities orders of magnitude stronger than those of the analogous thioesters, the corresponding substrate glycine derivatives or the natural substrate procalcitonin.",

author = "Feihua Cao and Gamble, {Allan B.} and Kim, {Hye Kyung} and Hideki Onagi and Gresser, {Mary J.} and Jamie Kerr and Easton, {Christopher J.}",

year = "2011",

month = aug,

doi = "10.1039/c1md00079a",

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AU - Cao, Feihua

AU - Gamble, Allan B.

AU - Kim, Hye Kyung

AU - Onagi, Hideki

AU - Gresser, Mary J.

AU - Kerr, Jamie

AU - Easton, Christopher J.

PY - 2011/8

Y1 - 2011/8

N2 - Fatty acid glycolates are nanomolar inhibitors of small cell lung carcinoma peptidylglycine α-amidating monooxygenase, with binding affinities orders of magnitude stronger than those of the analogous thioesters, the corresponding substrate glycine derivatives or the natural substrate procalcitonin.

AB - Fatty acid glycolates are nanomolar inhibitors of small cell lung carcinoma peptidylglycine α-amidating monooxygenase, with binding affinities orders of magnitude stronger than those of the analogous thioesters, the corresponding substrate glycine derivatives or the natural substrate procalcitonin.

UR - http://www.scopus.com/inward/record.url?scp=79961158916&partnerID=8YFLogxK

U2 - 10.1039/c1md00079a

DO - 10.1039/c1md00079a

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SN - 2040-2503

VL - 2

SP - 760

EP - 763

JO - MedChemComm

JF - MedChemComm

IS - 8

ER -

Potent and selective inhibitors of human peptidylglycine α-amidating monooxygenase

Abstract

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