TY - JOUR
T1 - Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages
AU - Ewart, Gary D.
AU - Nasr, Najla
AU - Naif, Hassan
AU - Cox, Graeme B.
AU - Cunningham, Anthony L.
AU - Gage, Peter W.
PY - 2004/6
Y1 - 2004/6
N2 - We report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.
AB - We report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.
UR - http://www.scopus.com/inward/record.url?scp=2542441626&partnerID=8YFLogxK
U2 - 10.1128/AAC.48.6.2325-2330.2004
DO - 10.1128/AAC.48.6.2325-2330.2004
M3 - Article
SN - 0066-4804
VL - 48
SP - 2325
EP - 2330
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 6
ER -