Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages

Gary D. Ewart; Najla Nasr; Hassan Naif; Graeme B. Cox; Anthony L. Cunningham; Peter W. Gage

doi:10.1128/AAC.48.6.2325-2330.2004

Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages

Gary D. Ewart^*
, Najla Nasr
, Hassan Naif
, Graeme B. Cox
, Anthony L. Cunningham
, Peter W. Gage

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

We report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.

Original language	English
Pages (from-to)	2325-2330
Number of pages	6
Journal	Antimicrobial Agents and Chemotherapy
Volume	48
Issue number	6
DOIs	https://doi.org/10.1128/AAC.48.6.2325-2330.2004
Publication status	Published - Jun 2004

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10.1128/AAC.48.6.2325-2330.2004

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title = "Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages",

abstract = "We report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.",

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AU - Ewart, Gary D.

AU - Nasr, Najla

AU - Naif, Hassan

AU - Cox, Graeme B.

AU - Cunningham, Anthony L.

AU - Gage, Peter W.

PY - 2004/6

Y1 - 2004/6

N2 - We report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.

AB - We report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.

UR - https://www.scopus.com/pages/publications/2542441626

U2 - 10.1128/AAC.48.6.2325-2330.2004

DO - 10.1128/AAC.48.6.2325-2330.2004

M3 - Article

SN - 0066-4804

VL - 48

SP - 2325

EP - 2330

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 6

ER -

Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages

Abstract

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