TY - JOUR
T1 - Predicting cognitive decline in healthy older adults
AU - De Jager, Celeste
AU - Blackwell, Andrew D.
AU - Budge, Marc M.
AU - Sahakian, Barbara J.
PY - 2005/8
Y1 - 2005/8
N2 - Objective: Authors performed a neuropsychological determination of which individuals in a group of community-dwelling, healthy elderly volunteers would develop cognitive decline. Methods: A group of 155 volunteers reporting good memory and thinking participated in a prospective study over 4 years. Authors monitored cognitive functioning and incidence of Mild Cognitive Impairment (MCI)/Alzheimer disease (AD). Results: Baseline assessment revealed a sub-group of participants with deficits in associative learning and naming; subsequent cognitive decline was more precipitous in these individuals, who also showed higher relative risk of MCI/AD. Conclusion: Cognitive measures may be useful in community and clinical dementia screening and applicable for identifying enriched samples for trials of anti-dementia treatments.
AB - Objective: Authors performed a neuropsychological determination of which individuals in a group of community-dwelling, healthy elderly volunteers would develop cognitive decline. Methods: A group of 155 volunteers reporting good memory and thinking participated in a prospective study over 4 years. Authors monitored cognitive functioning and incidence of Mild Cognitive Impairment (MCI)/Alzheimer disease (AD). Results: Baseline assessment revealed a sub-group of participants with deficits in associative learning and naming; subsequent cognitive decline was more precipitous in these individuals, who also showed higher relative risk of MCI/AD. Conclusion: Cognitive measures may be useful in community and clinical dementia screening and applicable for identifying enriched samples for trials of anti-dementia treatments.
UR - http://www.scopus.com/inward/record.url?scp=23944469309&partnerID=8YFLogxK
U2 - 10.1097/00019442-200508000-00014
DO - 10.1097/00019442-200508000-00014
M3 - Article
SN - 1064-7481
VL - 13
SP - 735
EP - 740
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 8
ER -