Predicting cognitive decline in healthy older adults

Celeste De Jager; Andrew D. Blackwell; Marc M. Budge; Barbara J. Sahakian

doi:10.1097/00019442-200508000-00014

Predicting cognitive decline in healthy older adults

Celeste De Jager, Andrew D. Blackwell, Marc M. Budge, Barbara J. Sahakian^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

Objective: Authors performed a neuropsychological determination of which individuals in a group of community-dwelling, healthy elderly volunteers would develop cognitive decline. Methods: A group of 155 volunteers reporting good memory and thinking participated in a prospective study over 4 years. Authors monitored cognitive functioning and incidence of Mild Cognitive Impairment (MCI)/Alzheimer disease (AD). Results: Baseline assessment revealed a sub-group of participants with deficits in associative learning and naming; subsequent cognitive decline was more precipitous in these individuals, who also showed higher relative risk of MCI/AD. Conclusion: Cognitive measures may be useful in community and clinical dementia screening and applicable for identifying enriched samples for trials of anti-dementia treatments.

Original language	English
Pages (from-to)	735-740
Number of pages	6
Journal	American Journal of Geriatric Psychiatry
Volume	13
Issue number	8
DOIs	https://doi.org/10.1097/00019442-200508000-00014
Publication status	Published - Aug 2005

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title = "Predicting cognitive decline in healthy older adults",

abstract = "Objective: Authors performed a neuropsychological determination of which individuals in a group of community-dwelling, healthy elderly volunteers would develop cognitive decline. Methods: A group of 155 volunteers reporting good memory and thinking participated in a prospective study over 4 years. Authors monitored cognitive functioning and incidence of Mild Cognitive Impairment (MCI)/Alzheimer disease (AD). Results: Baseline assessment revealed a sub-group of participants with deficits in associative learning and naming; subsequent cognitive decline was more precipitous in these individuals, who also showed higher relative risk of MCI/AD. Conclusion: Cognitive measures may be useful in community and clinical dementia screening and applicable for identifying enriched samples for trials of anti-dementia treatments.",

author = "\{De Jager\}, Celeste and Blackwell, \{Andrew D.\} and Budge, \{Marc M.\} and Sahakian, \{Barbara J.\}",

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AU - De Jager, Celeste

AU - Blackwell, Andrew D.

AU - Budge, Marc M.

AU - Sahakian, Barbara J.

PY - 2005/8

Y1 - 2005/8

N2 - Objective: Authors performed a neuropsychological determination of which individuals in a group of community-dwelling, healthy elderly volunteers would develop cognitive decline. Methods: A group of 155 volunteers reporting good memory and thinking participated in a prospective study over 4 years. Authors monitored cognitive functioning and incidence of Mild Cognitive Impairment (MCI)/Alzheimer disease (AD). Results: Baseline assessment revealed a sub-group of participants with deficits in associative learning and naming; subsequent cognitive decline was more precipitous in these individuals, who also showed higher relative risk of MCI/AD. Conclusion: Cognitive measures may be useful in community and clinical dementia screening and applicable for identifying enriched samples for trials of anti-dementia treatments.

AB - Objective: Authors performed a neuropsychological determination of which individuals in a group of community-dwelling, healthy elderly volunteers would develop cognitive decline. Methods: A group of 155 volunteers reporting good memory and thinking participated in a prospective study over 4 years. Authors monitored cognitive functioning and incidence of Mild Cognitive Impairment (MCI)/Alzheimer disease (AD). Results: Baseline assessment revealed a sub-group of participants with deficits in associative learning and naming; subsequent cognitive decline was more precipitous in these individuals, who also showed higher relative risk of MCI/AD. Conclusion: Cognitive measures may be useful in community and clinical dementia screening and applicable for identifying enriched samples for trials of anti-dementia treatments.

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DO - 10.1097/00019442-200508000-00014

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JO - American Journal of Geriatric Psychiatry

JF - American Journal of Geriatric Psychiatry

IS - 8

ER -

Predicting cognitive decline in healthy older adults

Abstract

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