Preparation of some angularly substituted and highly functionalized quinolizidines as building blocks for the synthesis of various alkaloids and related scaffolds of medicinal interest

Alex C. Bissember; Martin G. Banwell

doi:10.1016/j.tet.2009.07.067

Preparation of some angularly substituted and highly functionalized quinolizidines as building blocks for the synthesis of various alkaloids and related scaffolds of medicinal interest

Alex C. Bissember, Martin G. Banwell^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The epimeric forms of the angularly substituted quinolizidine 6, representing potentially useful building blocks for the synthesis of various alkaloids, have been prepared via a pathway involving two consecutive ring-closing metathesis reactions. Variously hydroxy-protected derivatives (21, 22, and 26-29) of these compounds have also been generated.

Original language	English
Pages (from-to)	8222-8230
Number of pages	9
Journal	Tetrahedron
Volume	65
Issue number	39
DOIs	https://doi.org/10.1016/j.tet.2009.07.067
Publication status	Published - 26 Sept 2009

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10.1016/j.tet.2009.07.067

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abstract = "The epimeric forms of the angularly substituted quinolizidine 6, representing potentially useful building blocks for the synthesis of various alkaloids, have been prepared via a pathway involving two consecutive ring-closing metathesis reactions. Variously hydroxy-protected derivatives (21, 22, and 26-29) of these compounds have also been generated.",

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AU - Banwell, Martin G.

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Y1 - 2009/9/26

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AB - The epimeric forms of the angularly substituted quinolizidine 6, representing potentially useful building blocks for the synthesis of various alkaloids, have been prepared via a pathway involving two consecutive ring-closing metathesis reactions. Variously hydroxy-protected derivatives (21, 22, and 26-29) of these compounds have also been generated.

KW - Alkaloids

KW - Fasicularin

KW - Quinolizidines

KW - Ring-closing metathesis

KW - Vinylation

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DO - 10.1016/j.tet.2009.07.067

M3 - Article

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VL - 65

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JO - Tetrahedron

JF - Tetrahedron

IS - 39

ER -

Preparation of some angularly substituted and highly functionalized quinolizidines as building blocks for the synthesis of various alkaloids and related scaffolds of medicinal interest

Abstract

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