Probing for the pharmacophore of the cytotoxic neoclerodane salvileucalin B

Nora Heinrich; Martin G. Banwell; Anthony C. Willis; Ian A. Cade; Robert J. Capon; Xiao Cong Huang

doi:10.1071/CH12358

Probing for the pharmacophore of the cytotoxic neoclerodane salvileucalin B

Nora Heinrich, Martin G. Banwell^*, Anthony C. Willis, Ian A. Cade, Robert J. Capon, Xiao Cong Huang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The novel [4.3.1]propelladiene 2, which embodies the key structural elements of the pentacyclic core of the cytotoxic neoclerodane salvileucalin B (1), has been prepared using a rhodium-catalysed intramolecular Bchner reaction as the key step. Compound 2 and the readily obtained derivatives 12-17 all proved to be essentially inactive when tested against a panel of four human cancer cell lines. Furthermore, not one of these compounds was a P-gp inhibitor.

Original language	English
Pages (from-to)	1679-1686
Number of pages	8
Journal	Australian Journal of Chemistry
Volume	65
Issue number	12
DOIs	https://doi.org/10.1071/CH12358
Publication status	Published - 2012

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AU - Huang, Xiao Cong

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AB - The novel [4.3.1]propelladiene 2, which embodies the key structural elements of the pentacyclic core of the cytotoxic neoclerodane salvileucalin B (1), has been prepared using a rhodium-catalysed intramolecular Bchner reaction as the key step. Compound 2 and the readily obtained derivatives 12-17 all proved to be essentially inactive when tested against a panel of four human cancer cell lines. Furthermore, not one of these compounds was a P-gp inhibitor.

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Probing for the pharmacophore of the cytotoxic neoclerodane salvileucalin B

Abstract

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