Production and regulation of levels of amidated peptide hormones

Feihua Cao, Christopher J. Easton*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)


    Peptide hormones with a C-terminal amide regulate numerous physiological processes and are associated with many disease states. Consequently, the key enzymes involved in their production, peptidylglycine α-amidating monooxygenase and carboxypeptidase E, have been studied intensively. This review surveys what is known about the enzymes themselves and their cofactors, as well as their substrates and competitive and mechanism-based inhibitors.

    Original languageEnglish
    Pages (from-to)297-307
    Number of pages11
    JournalAustralian Journal of Chemistry
    Issue number3
    Publication statusPublished - 2013


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