Profound lymphopenia and bacteraemia

C. A. Hawkins; P. Collignon; D. N. Adams; F. J. Bowden; M. C. Cook

doi:10.1111/j.1445-5994.2006.01076.x

Profound lymphopenia and bacteraemia

C. A. Hawkins^*, P. Collignon, D. N. Adams, F. J. Bowden, M. C. Cook

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Bacteraemia often carries a poor prognosis despite prompt antibiotic therapy and is associated with late morbidity and mortality that is difficult to explain. Here, we describe perisistent B- and T- cell lymphopenia in a cohort of patients with Gram-positive and Gram-negative bacteraemia. This suggests previously unrecognized mechanisms of subversion of immunity by pathogens and might explain the comorbidity of blood stream infection with bacteria.

Original language	English
Pages (from-to)	385-388
Number of pages	4
Journal	Internal Medicine Journal
Volume	36
Issue number	6
DOIs	https://doi.org/10.1111/j.1445-5994.2006.01076.x
Publication status	Published - Jun 2006

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10.1111/j.1445-5994.2006.01076.x

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title = "Profound lymphopenia and bacteraemia",

abstract = "Bacteraemia often carries a poor prognosis despite prompt antibiotic therapy and is associated with late morbidity and mortality that is difficult to explain. Here, we describe perisistent B- and T- cell lymphopenia in a cohort of patients with Gram-positive and Gram-negative bacteraemia. This suggests previously unrecognized mechanisms of subversion of immunity by pathogens and might explain the comorbidity of blood stream infection with bacteria.",

keywords = "B and T cell lymphopenia, Bacteraemia, Sepsis",

author = "Hawkins, {C. A.} and P. Collignon and Adams, {D. N.} and Bowden, {F. J.} and Cook, {M. C.}",

year = "2006",

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AU - Hawkins, C. A.

AU - Collignon, P.

AU - Adams, D. N.

AU - Bowden, F. J.

AU - Cook, M. C.

PY - 2006/6

Y1 - 2006/6

N2 - Bacteraemia often carries a poor prognosis despite prompt antibiotic therapy and is associated with late morbidity and mortality that is difficult to explain. Here, we describe perisistent B- and T- cell lymphopenia in a cohort of patients with Gram-positive and Gram-negative bacteraemia. This suggests previously unrecognized mechanisms of subversion of immunity by pathogens and might explain the comorbidity of blood stream infection with bacteria.

AB - Bacteraemia often carries a poor prognosis despite prompt antibiotic therapy and is associated with late morbidity and mortality that is difficult to explain. Here, we describe perisistent B- and T- cell lymphopenia in a cohort of patients with Gram-positive and Gram-negative bacteraemia. This suggests previously unrecognized mechanisms of subversion of immunity by pathogens and might explain the comorbidity of blood stream infection with bacteria.

KW - B and T cell lymphopenia

KW - Bacteraemia

KW - Sepsis

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U2 - 10.1111/j.1445-5994.2006.01076.x

DO - 10.1111/j.1445-5994.2006.01076.x

M3 - Article

SN - 1444-0903

VL - 36

SP - 385

EP - 388

JO - Internal Medicine Journal

JF - Internal Medicine Journal

IS - 6

ER -

Profound lymphopenia and bacteraemia

Abstract

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