Promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus is associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy

Georgia Kaidonis; Jamie E. Craig; Mark C. Gillies; Sotoodeh Abhary; Rohan W. Essex; John H. Chang; Bishwanath Pal; Maria Pefkianaki; Mark Daniell; Stewart Lake; Nikolai Petrovsky; Kathryn P. Burdon

doi:10.1177/1479164115616902

Promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus is associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy

Georgia Kaidonis^*, Jamie E. Craig, Mark C. Gillies, Sotoodeh Abhary, Rohan W. Essex, John H. Chang, Bishwanath Pal, Maria Pefkianaki, Mark Daniell, Stewart Lake, Nikolai Petrovsky, Kathryn P. Burdon

^*Corresponding author for this work

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6 Citations (Scopus)

Abstract

Aim: To investigate, in a large cohort of 2494 individuals with diabetes mellitus, whether functional single nucleotide polymorphisms in the promoter region of tumour necrosis factor (TNF) and lymphotoxin-alpha (LTA) genes are associated with type of diabetes or presence of diabetic retinopathy. Methods: A total of 334 type 1 diabetes and 999 type 2 diabetes participants with sight-threatening diabetic retinopathy, and 260 type 1 diabetes and 901 type 2 diabetes participants with no diabetic retinopathy or minimal non-proliferative diabetic retinopathy, were genotyped for two single nucleotide polymorphisms (rs1800629 and rs361525). Results: The A allele of rs1800629 was associated with type 1 diabetes (p < 0.001; odds ratio = 0.62). After adjustment for age, sex, diabetes duration, HbA1c, hypertension and nephropathy, no significant association was found between rs1800629 or rs361525 and sight-threatening diabetic retinopathy. Conclusion: An association between the A allele of rs1800629 and type of diabetes was found. No association was found between two promoter variants of TNF and LTA, and diabetic retinopathy in a large cohort of Caucasian patients with type 1 diabetes and type 2 diabetes.

Original language	English
Pages (from-to)	164-167
Number of pages	4
Journal	Diabetes and Vascular Disease Research
Volume	13
Issue number	2
DOIs	https://doi.org/10.1177/1479164115616902
Publication status	Published - 1 Mar 2016

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Kaidonis, G., Craig, J. E., Gillies, M. C., Abhary, S., Essex, R. W., Chang, J. H., Pal, B., Pefkianaki, M., Daniell, M., Lake, S., Petrovsky, N., & Burdon, K. P. (2016). Promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus is associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy. Diabetes and Vascular Disease Research, 13(2), 164-167. https://doi.org/10.1177/1479164115616902

@article{ef5c21ce91f342e9aea81d0ccaac226a,

title = "Promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus is associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy",

abstract = "Aim: To investigate, in a large cohort of 2494 individuals with diabetes mellitus, whether functional single nucleotide polymorphisms in the promoter region of tumour necrosis factor (TNF) and lymphotoxin-alpha (LTA) genes are associated with type of diabetes or presence of diabetic retinopathy. Methods: A total of 334 type 1 diabetes and 999 type 2 diabetes participants with sight-threatening diabetic retinopathy, and 260 type 1 diabetes and 901 type 2 diabetes participants with no diabetic retinopathy or minimal non-proliferative diabetic retinopathy, were genotyped for two single nucleotide polymorphisms (rs1800629 and rs361525). Results: The A allele of rs1800629 was associated with type 1 diabetes (p < 0.001; odds ratio = 0.62). After adjustment for age, sex, diabetes duration, HbA1c, hypertension and nephropathy, no significant association was found between rs1800629 or rs361525 and sight-threatening diabetic retinopathy. Conclusion: An association between the A allele of rs1800629 and type of diabetes was found. No association was found between two promoter variants of TNF and LTA, and diabetic retinopathy in a large cohort of Caucasian patients with type 1 diabetes and type 2 diabetes.",

keywords = "Diabetic retinopathy, diabetes, genetics, lymphotoxin-alpha, tumour necrosis factor",

author = "Georgia Kaidonis and Craig, {Jamie E.} and Gillies, {Mark C.} and Sotoodeh Abhary and Essex, {Rohan W.} and Chang, {John H.} and Bishwanath Pal and Maria Pefkianaki and Mark Daniell and Stewart Lake and Nikolai Petrovsky and Burdon, {Kathryn P.}",

note = "Publisher Copyright: {\textcopyright} SAGE Publications.",

year = "2016",

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day = "1",

doi = "10.1177/1479164115616902",

language = "English",

volume = "13",

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journal = "Diabetes and Vascular Disease Research",

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Kaidonis, G, Craig, JE, Gillies, MC, Abhary, S, Essex, RW, Chang, JH, Pal, B, Pefkianaki, M, Daniell, M, Lake, S, Petrovsky, N & Burdon, KP 2016, 'Promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus is associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy', Diabetes and Vascular Disease Research, vol. 13, no. 2, pp. 164-167. https://doi.org/10.1177/1479164115616902

Promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus is associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy. / Kaidonis, Georgia; Craig, Jamie E.; Gillies, Mark C. et al.
In: Diabetes and Vascular Disease Research, Vol. 13, No. 2, 01.03.2016, p. 164-167.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus is associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy

AU - Kaidonis, Georgia

AU - Craig, Jamie E.

AU - Gillies, Mark C.

AU - Abhary, Sotoodeh

AU - Essex, Rohan W.

AU - Chang, John H.

AU - Pal, Bishwanath

AU - Pefkianaki, Maria

AU - Daniell, Mark

AU - Lake, Stewart

AU - Petrovsky, Nikolai

AU - Burdon, Kathryn P.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Aim: To investigate, in a large cohort of 2494 individuals with diabetes mellitus, whether functional single nucleotide polymorphisms in the promoter region of tumour necrosis factor (TNF) and lymphotoxin-alpha (LTA) genes are associated with type of diabetes or presence of diabetic retinopathy. Methods: A total of 334 type 1 diabetes and 999 type 2 diabetes participants with sight-threatening diabetic retinopathy, and 260 type 1 diabetes and 901 type 2 diabetes participants with no diabetic retinopathy or minimal non-proliferative diabetic retinopathy, were genotyped for two single nucleotide polymorphisms (rs1800629 and rs361525). Results: The A allele of rs1800629 was associated with type 1 diabetes (p < 0.001; odds ratio = 0.62). After adjustment for age, sex, diabetes duration, HbA1c, hypertension and nephropathy, no significant association was found between rs1800629 or rs361525 and sight-threatening diabetic retinopathy. Conclusion: An association between the A allele of rs1800629 and type of diabetes was found. No association was found between two promoter variants of TNF and LTA, and diabetic retinopathy in a large cohort of Caucasian patients with type 1 diabetes and type 2 diabetes.

AB - Aim: To investigate, in a large cohort of 2494 individuals with diabetes mellitus, whether functional single nucleotide polymorphisms in the promoter region of tumour necrosis factor (TNF) and lymphotoxin-alpha (LTA) genes are associated with type of diabetes or presence of diabetic retinopathy. Methods: A total of 334 type 1 diabetes and 999 type 2 diabetes participants with sight-threatening diabetic retinopathy, and 260 type 1 diabetes and 901 type 2 diabetes participants with no diabetic retinopathy or minimal non-proliferative diabetic retinopathy, were genotyped for two single nucleotide polymorphisms (rs1800629 and rs361525). Results: The A allele of rs1800629 was associated with type 1 diabetes (p < 0.001; odds ratio = 0.62). After adjustment for age, sex, diabetes duration, HbA1c, hypertension and nephropathy, no significant association was found between rs1800629 or rs361525 and sight-threatening diabetic retinopathy. Conclusion: An association between the A allele of rs1800629 and type of diabetes was found. No association was found between two promoter variants of TNF and LTA, and diabetic retinopathy in a large cohort of Caucasian patients with type 1 diabetes and type 2 diabetes.

KW - Diabetic retinopathy

KW - diabetes

KW - genetics

KW - lymphotoxin-alpha

KW - tumour necrosis factor

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U2 - 10.1177/1479164115616902

DO - 10.1177/1479164115616902

M3 - Article

SN - 1479-1641

VL - 13

SP - 164

EP - 167

JO - Diabetes and Vascular Disease Research

JF - Diabetes and Vascular Disease Research

IS - 2

ER -

Promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus is associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy

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