Protein delivery to membranes: Patent No. US11723985B2

Adam Willis Perriman; Robert Christopher Deller; Wenjin  Xiao; Thomas Iain Phillip Green; Benjamin Michael Carter; Graham John Day; Rosalia Cuahtecontzi Delint

Protein delivery to membranes: Patent No. US11723985B2

Adam Willis Perriman, Robert Christopher Deller, Wenjin Xiao, Thomas Iain Phillip Green, Benjamin Michael Carter, Graham John Day, Rosalia Cuahtecontzi Delint

Research output: Other contribution

Abstract

United States Patent
Perriman et al.

Patent No.: US 11,723,985 B2
Date of Patent: Aug. 15, 2023

PROTEIN DELIVERY TO MEMBRANES
Applicant: CYTOSEEK LIMITED, Bristol (GB)

There is provided a phospholipid composition which is a bilayer or micelle comprising at least one embedded protein-polymer surfactant conjugate comprising an anchor protein, wherein the anchor protein is a cationised protein or an anionised protein, the composition characterised in that the anchor protein is: a) an active enzyme; or b) is a protein which does not comprise a -CH2C(O)NCH3(CH2)3NCH3) 2H+ linker covalently bonded to an amino acid side chain.

26 Claims, 12 Drawing Sheets
Specification includes a Sequence Listing.

Original language	English
Media of output	Patent
Publisher	US Patent and Trademark Office
Number of pages	93
Publication status	Published - 15 Aug 2023
Externally published	Yes

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title = "Protein delivery to membranes: Patent No. US11723985B2",

abstract = "United States Patent Perriman et al. Patent No.: US 11,723,985 B2 Date of Patent: Aug. 15, 2023 PROTEIN DELIVERY TO MEMBRANES Applicant: CYTOSEEK LIMITED, Bristol (GB) There is provided a phospholipid composition which is a bilayer or micelle comprising at least one embedded protein-polymer surfactant conjugate comprising an anchor protein, wherein the anchor protein is a cationised protein or an anionised protein, the composition characterised in that the anchor protein is: a) an active enzyme; or b) is a protein which does not comprise a -CH2C(O)NCH3(CH2)3NCH3) 2H+ linker covalently bonded to an amino acid side chain. 26 Claims, 12 Drawing Sheets Specification includes a Sequence Listing.",

author = "Perriman, \{Adam Willis\} and Deller, \{Robert Christopher\} and Wenjin Xiao and Green, \{Thomas Iain Phillip\} and Carter, \{Benjamin Michael\} and Day, \{Graham John\} and Delint, \{Rosalia Cuahtecontzi\}",

note = "US Patent 11,723,985",

year = "2023",

month = aug,

day = "15",

language = "English",

publisher = "US Patent and Trademark Office",

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TY - GEN

T1 - Protein delivery to membranes

T2 - Patent No. US11723985B2

AU - Perriman, Adam Willis

AU - Deller, Robert Christopher

AU - Xiao, Wenjin

AU - Green, Thomas Iain Phillip

AU - Carter, Benjamin Michael

AU - Day, Graham John

AU - Delint, Rosalia Cuahtecontzi

N1 - US Patent 11,723,985

PY - 2023/8/15

Y1 - 2023/8/15

N2 - United States Patent Perriman et al. Patent No.: US 11,723,985 B2 Date of Patent: Aug. 15, 2023 PROTEIN DELIVERY TO MEMBRANES Applicant: CYTOSEEK LIMITED, Bristol (GB) There is provided a phospholipid composition which is a bilayer or micelle comprising at least one embedded protein-polymer surfactant conjugate comprising an anchor protein, wherein the anchor protein is a cationised protein or an anionised protein, the composition characterised in that the anchor protein is: a) an active enzyme; or b) is a protein which does not comprise a -CH2C(O)NCH3(CH2)3NCH3) 2H+ linker covalently bonded to an amino acid side chain. 26 Claims, 12 Drawing Sheets Specification includes a Sequence Listing.

AB - United States Patent Perriman et al. Patent No.: US 11,723,985 B2 Date of Patent: Aug. 15, 2023 PROTEIN DELIVERY TO MEMBRANES Applicant: CYTOSEEK LIMITED, Bristol (GB) There is provided a phospholipid composition which is a bilayer or micelle comprising at least one embedded protein-polymer surfactant conjugate comprising an anchor protein, wherein the anchor protein is a cationised protein or an anionised protein, the composition characterised in that the anchor protein is: a) an active enzyme; or b) is a protein which does not comprise a -CH2C(O)NCH3(CH2)3NCH3) 2H+ linker covalently bonded to an amino acid side chain. 26 Claims, 12 Drawing Sheets Specification includes a Sequence Listing.

M3 - Other contribution

PB - US Patent and Trademark Office

ER -

Protein delivery to membranes: Patent No. US11723985B2

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