Protein nanofibres of defined morphology prepared from mixtures of crude crystallins

M. Garvey, S. L. Gras, S. Meehan, S. J. Meade, J. A. Carver, J. A. Gerrard

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Self assembling protein nanofibres have great potential within the nanotechnology industry. To realise this potential, nanofibres need to be manufactured on a commercial scale. To date, amyloid fibrils, a form of protein nanofibre with desirable bionanotechnological properties, have only been produced using expensive and time-costly, small-scale methods. This paper describes the production of protein nanofibres from semi-pure and crude mixtures of bovine crystallin proteins, currently a waste product in the meat industry. These nanofibres displayed amyloid fibril characteristics. Moreover, distinct fibre morphologies were observed dependent upon the formation conditions adopted. This research shows that amyloid fibrils can be inexpensively produced from crude crystallin protein mixtures, making them a potential industrial source for protein nanofibres.

Original languageEnglish
Pages (from-to)258-273
Number of pages16
JournalInternational Journal of Nanotechnology
Issue number3-4
Publication statusPublished - Feb 2009
Externally publishedYes


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