Psychosis with obsessive-compulsive symptoms in tuberous sclerosis

Islam K. Hassan; Jeffrey C.L. Looi; Dennis Velakoulis; Frank Gaillard; Elaine H. Lui; Terence J. O'Brien; Chris French; Campbell Le Heron; Sophia J. Adams

doi:10.1016/j.jocn.2013.08.005

Psychosis with obsessive-compulsive symptoms in tuberous sclerosis

Islam K. Hassan^*, Jeffrey C.L. Looi, Dennis Velakoulis, Frank Gaillard, Elaine H. Lui, Terence J. O'Brien, Chris French, Campbell Le Heron, Sophia J. Adams

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We present a case of tuberous sclerosis complex (TSC) diagnosed in adulthood in a man initially referred for specialist neuropsychiatric assessment with psychosis and obsessive-compulsive symptoms (OCS) on a background of epilepsy and intellectual disability. To our knowledge, this is the first reported patient with TSC featuring both psychosis and OCS. This patient highlights the importance of comprehensive re-evaluation of atypical presentations of intellectual disability, epilepsy and associated neuropsychiatric symptoms, even in adulthood. This is particularly relevant in the context of significant advances in genetics, neuroscience, imaging and treatments for heritable neurogenetic disorders.

Original language	English
Pages (from-to)	867-869
Number of pages	3
Journal	Journal of Clinical Neuroscience
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/j.jocn.2013.08.005
Publication status	Published - May 2014

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title = "Psychosis with obsessive-compulsive symptoms in tuberous sclerosis",

abstract = "We present a case of tuberous sclerosis complex (TSC) diagnosed in adulthood in a man initially referred for specialist neuropsychiatric assessment with psychosis and obsessive-compulsive symptoms (OCS) on a background of epilepsy and intellectual disability. To our knowledge, this is the first reported patient with TSC featuring both psychosis and OCS. This patient highlights the importance of comprehensive re-evaluation of atypical presentations of intellectual disability, epilepsy and associated neuropsychiatric symptoms, even in adulthood. This is particularly relevant in the context of significant advances in genetics, neuroscience, imaging and treatments for heritable neurogenetic disorders.",

keywords = "Epilepsy, Neuropsychiatry, Obsessive compulsive disorder, Psychosis, Tuberous sclerosis",

author = "Hassan, {Islam K.} and Looi, {Jeffrey C.L.} and Dennis Velakoulis and Frank Gaillard and Lui, {Elaine H.} and O'Brien, {Terence J.} and Chris French and {Le Heron}, Campbell and Adams, {Sophia J.}",

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AU - Hassan, Islam K.

AU - Looi, Jeffrey C.L.

AU - Velakoulis, Dennis

AU - Gaillard, Frank

AU - Lui, Elaine H.

AU - O'Brien, Terence J.

AU - French, Chris

AU - Le Heron, Campbell

AU - Adams, Sophia J.

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N2 - We present a case of tuberous sclerosis complex (TSC) diagnosed in adulthood in a man initially referred for specialist neuropsychiatric assessment with psychosis and obsessive-compulsive symptoms (OCS) on a background of epilepsy and intellectual disability. To our knowledge, this is the first reported patient with TSC featuring both psychosis and OCS. This patient highlights the importance of comprehensive re-evaluation of atypical presentations of intellectual disability, epilepsy and associated neuropsychiatric symptoms, even in adulthood. This is particularly relevant in the context of significant advances in genetics, neuroscience, imaging and treatments for heritable neurogenetic disorders.

AB - We present a case of tuberous sclerosis complex (TSC) diagnosed in adulthood in a man initially referred for specialist neuropsychiatric assessment with psychosis and obsessive-compulsive symptoms (OCS) on a background of epilepsy and intellectual disability. To our knowledge, this is the first reported patient with TSC featuring both psychosis and OCS. This patient highlights the importance of comprehensive re-evaluation of atypical presentations of intellectual disability, epilepsy and associated neuropsychiatric symptoms, even in adulthood. This is particularly relevant in the context of significant advances in genetics, neuroscience, imaging and treatments for heritable neurogenetic disorders.

KW - Epilepsy

KW - Neuropsychiatry

KW - Obsessive compulsive disorder

KW - Psychosis

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DO - 10.1016/j.jocn.2013.08.005

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SP - 867

EP - 869

JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

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Psychosis with obsessive-compulsive symptoms in tuberous sclerosis

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