Pupillary response to sparse multifocal stimuli in multiple sclerosis patients

Eman N. Ali*, T. Maddess, A. C. James, C. Voicu, C. J. Lueck

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)


    The objective of this paper is to investigate the pattern of abnormalities and establish the diagnostic power of multifocal objective pupil perimetry (mfPOP) in multiple sclerosis (MS). Methods: A prospective study enrolling 35 normal (47.9 ± 16.8 years, 22 females) and 85 MS subjects (49.8 ± 11.3 years, 62 females; 72 relapsing-remitting (RR), and 13 primary or secondary progressives (PorS)). EDSS scores for the RR and PorS groups were 3.53 ± 1.04 (mean ± SD), and 5.9 ± 1.43, respectively. mfPOP responses were obtained from 44 regions/visual field. Each region was analysed according to response time-to-peak and standardised amplitude (AmpStd). Predictive power was measured by percentage area under the receiver operator curve (%AUC). Results: mfPOP responses showed a significant reduction of 0.69 ± 0.04 dB (mean ± SE) in AmpStd and significantly delayed time-to-peak of 25.95 ± 0.89 ms (mean ± SE) in MS subjects compared to control subjects (p<0.001). %AUC was greater for time-to-peak than AmpStd both for RR and PorS patients. Diagnostic power followed the EDSS scores but not a history of optic neuritis.Conclusions: mfPOP is well tolerated and potentially has a role in the diagnosis and assessment of patients with MS.

    Original languageEnglish
    Pages (from-to)854-861
    Number of pages8
    JournalMultiple Sclerosis Journal
    Issue number7
    Publication statusPublished - Jun 2014


    Dive into the research topics of 'Pupillary response to sparse multifocal stimuli in multiple sclerosis patients'. Together they form a unique fingerprint.

    Cite this